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Title

Folate and Vitamin B12 concentrations are associated with plasma DHA and EPA fatty acids in European adolescents: the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) study

AuthorsIglesia, Iris; Huybrechts, Inge; González Gross, Marcela; Mouratidou, Theodora; Santabárbara, Javier; Chajès, V.; González-Gil, Esther; Park, J. Y.; Bel-Serrat, Silvia; Cuenca-García, Magdalena; Castillo, Manuel J.; Kersting, Mathilde; Widhalm, Kurt; De Henauw, Stefaan; Sjöström, Michael; Gottrand, Frederic; Molnar, Denes; Manios, Yannis; Kafatos, Anthony; Ferrari, Marika; Stehle, Peter; Marcos, Ascensión ; Sánchez-Muniz, F. J.; Moreno, Luis A.
KeywordsPhospholipids
Fatty acids
Europe
B-vitamins
Adolescents
tHcy homocysteine
S-adenosyl- l -homocysteine
Pyridoxal 5'-phosphate
Plasma folate
Phosphatidylcholine
Healthy Lifestyle in Europe by Nutrition in Adolescence
HELENA
Diet quality index
Fatty acids
Issue Date2017
PublisherCambridge University Press
CitationBritish Journal of Nutrition 117(1): 124-133 (2017)
AbstractThis study aimed to examine the association between vitamin B6, folate and vitamin B12 biomarkers and plasma fatty acids in European adolescents. A subsample from the Healthy Lifestyle in Europe by Nutrition in Adolescence study with valid data on B-vitamins and fatty acid blood parameters, and all the other covariates used in the analyses such as BMI, Diet Quality Index, education of the mother and physical activity assessed by a questionnaire, was selected resulting in 674 cases (43 % males). B-vitamin biomarkers were measured by chromatography and immunoassay and fatty acids by enzymatic analyses. Linear mixed models elucidated the association between B-vitamins and fatty acid blood parameters (changes in fatty acid profiles according to change in 10 units of vitamin B biomarkers). DHA, EPA) and n-3 fatty acids showed positive associations with B-vitamin biomarkers, mainly with those corresponding to folate and vitamin B12. Contrarily, negative associations were found with n-6:n-3 ratio, trans-fatty acids and oleic:stearic ratio. With total homocysteine (tHcy), all the associations found with these parameters were opposite (for instance, an increase of 10 nmol/l in red blood cell folate or holotranscobalamin in females produces an increase of 15·85 Âmol/l of EPA (P value <0·01), whereas an increase of 10 nmol/l of tHcy in males produces a decrease of 2·06 Âmol/l of DHA (P value <0·05). Positive associations between B-vitamins and specific fatty acids might suggest underlying mechanisms between B-vitamins and CVD and it is worth the attention of public health policies.
DescriptionOn behalf of the HELENA Study Group.
Publisher version (URL)https://doi.org/10.1017/S0007114516004414
URIhttp://hdl.handle.net/10261/171337
Identifiersdoi: 10.1017/S0007114516004414
e-issn: 1475-2662
issn: 0007-1145
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