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Comparison of definitions for the metabolic syndrome in adolescents. The HELENA study

AuthorsVanlancker, Tine; Schaubroeck, Emmily; Vyncke, K. E.; Cadenas-Sanchez, Cristina; Breidenassel, C.; González Gross, Marcela; Gottrand, Frederic; Moreno, Luis A.; Béghin, Laurent; Molnar, Denes; Manios, Yannis; Gunter, Marc J.; Widhalm, Kurt; Leclercq, Catherine; Dallongeville, J.; Marcos, Ascensión CSIC ORCID; Kafatos, Anthony; Castillo, Manuel J.; De Henauw, Stefaan; Ortega, F. B.; Huybrechts, Inge
KeywordsInsulin resistance
Metabolic risk factors
Metabolic criteria
Issue Date2017
PublisherSpringer Nature
CitationEuropean Journal of Pediatrics 176(2): 241-252 (2017)
AbstractVarious definitions are used to define metabolic syndrome in adolescents. This study aimed to compare, in terms of prevalence and differences, five frequently used definitions for this population: International Diabetes Federation, National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP) modified by Cook, pediatric American Heart Association (AHA), World Health Organization, and Jolliffe and Janssen. A sample of 1004 adolescents (12.5–17.0 years) from the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) study was considered. The components of the definitions (waist circumference/BMI, plasma lipids, glycemia, and blood pressure) were applied, and definitions were compared by using crosstabs, sensitivity, specificity, and kappa coefficient. The prevalence of metabolic syndrome varied from 1.6 to 3.8% depending on the used definitions. Crosstabs comparing the definitions showed the fewest cases being misclassified (having metabolic syndrome or not) between NCEP-ATP and AHA. Analyses for kappa coefficient, sensitivity, and specificity confirmed this finding. [Conclusion]: The different definitions do not classify the same adolescents as having MS and prevalence varied between diagnostic methods. The modified NCEP-ATP and the AHA definitions were most analogous in defining subjects as having metabolic syndrome or not.
DescriptionOn behalf of the HELENA project group.
Identifiersdoi: 10.1007/s00431-016-2831-6
e-issn: 1432-1076
issn: 0340-6199
Appears in Collections:(ICTAN) Artículos
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