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Título: | Sensitizing and eliciting capacity of egg white proteins in BALB/c mice as affected by processing |
Autor: | Pablos-Tanarro, Alba CSIC ORCID; Lozano-Ojalvo, Daniel CSIC ORCID; Martínez-Blanco, Mónica CSIC ORCID; López-Fandiño, Rosina CSIC ORCID ; Molina, Elena CSIC ORCID | Palabras clave: | IgG1 Sensitization IgE Anaphylaxis High pressure Heat treatment Egg allergy BALB/c |
Fecha de publicación: | 2017 | Editor: | American Chemical Society | Citación: | Journal of Agricultural and Food Chemistry 65(22): 4500-4508 (2017) | Resumen: | This study assesses to what extent technological processes that lead to different degrees of denaturation of egg white proteins affect their allergenicity. We focused on heat (80 °C, 10 min) and high-pressure (400 MPa and 37 °C, 10 min) treatments and used a BALB/c mouse model of food allergy. Oral sensitization to egg white using cholera toxin as adjuvant induced the production of IgE and IgG1 isotypes and led to severe clinical signs following challenge with the allergen. Extensive protein denaturation caused by heat treatment increased its ability to induce Th1 responses and reduced both its sensitizing and eliciting capacity. Heated egg white stimulated the production of IgE over IgG1 antibodies directed, at least in part, toward new epitopes exposed as a result of heat treatment. Conversely, partial denaturation caused by high-pressure treatment increased the ability of egg white to stimulate Th2 responses and its allergenic potential. | URI: | http://hdl.handle.net/10261/171108 | DOI: | 10.1021/acs.jafc.7b00953 | Identificadores: | doi: 10.1021/acs.jafc.7b00953 e-issn: 1520-5118 issn: 0021-8561 |
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