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Production of the bioactive isoflavone O-desmethylangolensin by Enterococcus faecium INIA P553 with high efficiency

AuthorsGaya, Pilar; Peirotén, Ángela; Álvarez Acero, Inmaculada ; Medina, Margarita; Landete, José María
KeywordsEnterococcus faecium
Issue Date2018
CitationJournal of Functional Foods 40: 180-186 (2018)
AbstractHealthy effect of isoflavones consumption is attributed to their bioactive metabolites such as O-desmethylangolensin (O-DMA) produced by intestinal bacteria. Evidence from in vitro studies suggests that O-DMA has several cancer-related biological actions. Enterococcus spp. are indigenous species of the human gastrointestinal tract. Significant attention has been focused on Enterococcus faecium strains with probiotic and /or technological interest in foods. In this work, we describe the production of the bioactive isoflavones O-DMA and 6-hydroxy O-DMA by the strain E. faecium INIA P553. O-DMA was produced from dihydrodaidzein, daidzein, daidzin and formononetin, and 6-hydroxy O-DMA from dihydrogenistein, genistein and genistin with high efficiency. To our knowledge, it is the first bacterium with probiotic potential capable of producing O-DMA and 6-hydroxy O-DMA. Therefore, this strain shows potential applications in biotechnology in functional foods and as probiotic.
Identifiersdoi: 10.1016/j.jff.2017.11.008
issn: 1756-4646
e-issn: 2214-9414
Appears in Collections:(ICTAN) Artículos
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