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Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/17073

D-amino acids govern stationary phase cell wall remodeling in bacteria

AutorLam, Hubert; Oh, Dong-Chan; Cava, Felipe ; Takacs, Constantin N.; Clardy, Jon; Pedro, Miguel Ángel de; Waldor, Matthew K.
Fecha de publicación18-sep-2009
EditorAmerican Association for the Advancement of Science
CitaciónScience 325(5947): 1552-1555 (2009)
ResumenIn all known organisms, amino acids are predominantly thought to be synthesized and used as their L-enantiomers. Here, we found that bacteria produce diverse D-amino acids as well, which accumulate at millimolar concentrations in supernatants of stationary phase cultures. In Vibrio cholerae, a dedicated racemase produced D-Met and D-Leu, whereas Bacillus subtilis generated D-Tyr and D-Phe. These unusual D-amino acids appear to modulate synthesis of peptidoglycan, a strong and elastic polymer that serves as the stress-bearing component of the bacterial cell wall. D-Amino acids influenced peptidoglycan composition, amount, and strength, both by means of their incorporation into the polymer and by regulating enzymes that synthesize and modify it. Thus, synthesis of D-amino acids may be a common strategy for bacteria to adapt to changing environmental conditions.
Descripción4 pages, 4 figures.-- PMID: 19762646 [PubMed].-- Supporting information available at: http://www.sciencemag.org/cgi/content/full/sci;325/5947/1552/DC1
Versión del editorhttp://dx.doi.org/10.1126/science.1178123
ISSN0036-8075 (Print)
1095-9203 (Online)
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