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Título

Daily rhythms in the somatotropic axis of Senegalese sole (Solea senegalensis): The time of day influences the response to GH administration

AutorLópez-Olmeda, J. F.; Pujante Rodríguez, Isabel; Costa, L. S.; Galal-Khallaf, Asmaa; Mancera, Juan Miguel; Sánchez-Vázquez, F. J.
Palabras claveFlatfish
GH chronopharmacology
Growth hormone
Insulin-like growth factor
Pituitary adenylate cyclase-activating polypeptide
Fecha de publicación2016
EditorTaylor & Francis
CitaciónChronobiology International 33(3): 257-267 (2016)
ResumenGrowth factors in vertebrates display daily rhythms, which, while widely described in mammals, are still poorly understood in teleost fish. Here, we investigated the existence of daily rhythms in the somatotropic axis of the flatfish Solea senegalensis. In a first experiment, daily rhythms of the expression of pituitary adenylate cyclase–activating polypeptide (pacap), growth hormone (gh), insulin-like growth factor 1 (igf1) and its receptor (igf1r) were analyzed under a 12:12 h light:dark cycle. All genes displayed daily rhythms with the acrophases of pacap, gh and igf1 located in the second half of the dark phase (ZT 20:28–0:04 h), whereas the acrophase of igf1r was located around mid-light (ZT 5:33 h). In a second experiment, the influence of the time of day (mid-light, ML, versus mid-darkness, MD) of GH administration on the expression of these factors and on plasma glucose levels was tested. The response observed depended on the time of injection: the strongest effects were observed at MD, when GH administration significantly reduced pituitary gh and enhanced liver igf1 expression. These results provide the first evidence of daily rhythms and differential day/night effects in growth factors in S. senegalensis, suggesting new insights for investigating the physiology of growth and possible applications to improve fish aquaculture.
Versión del editorhttps://doi.org/10.3109/07420528.2015.1111379
URIhttp://hdl.handle.net/10261/170610
DOI10.3109/07420528.2015.1111379
ISSN0742-0528
E-ISSN1525-6073
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