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Bis(methyl)gliotoxin proves to be a more stable and reliable marker for invasive aspergillosis than gliotoxin and suitable for use in diagnosis

AutorDomingo, María P.; Colmenarejo, Cristina; Martínez-Lostao, Luis; Müllbacherd, Arno; Jarne, Carmen; Revillo, María J.; Delgado, Pilar ; Roc, Lourdes; Meis, Jacques F.; Rezusta, Antonio; Pardo, Julian; Gálvez Buerba, Eva Mª
Palabras claveInvasive aspergillosis
Diagnosis
Secondary metabolites
Gliotoxin
Bis(methylthio)gliotoxin
Fecha de publicación4-abr-2012
EditorElsevier
CitaciónDiagnostic Microbiology and Infectious Disease 73:57-64 (2012)
ResumenThe virulence factor gliotoxin (GT) and its inactive derivative, bis(methylthio)gliotoxin (bmGT), are produced by pathogens of the genus Aspergillus. Here we report the detection of GT and bmGT in serum of humans at risk of invasive aspergillosis (IA) as well as in cultures of fungal isolates derived from patients with proven infection with A. fumigatus. Although both compounds are readily recoverable from spiked human serum or plasma, only bmGT is retained in whole blood, indicating that bmGT may be the better marker for in vivo detection. Accordingly, bmGT was found more frequently than GT in samples from patients at risk of IA and in cultures of clinical isolates of A. fumigatus. In some cases, bmGT was detected before mycologic evidence of infection was gained. Importantly, neither GT nor bmGT was found in serum from healthy donors or from neutropenic patients without any sign of infection. Thus, bmGT presence might provide a more reliable indicator of A. fumigatus infections than GT. Due to its simplicity and sensitivity, a diagnostic technology based on this test could be easily adopted in clinical laboratories to help in the diagnosis of this often fatal fungal infection.
Versión del editorhttps://doi.org/10.1016/j.diagmicrobio.2012.01.012
URIhttp://hdl.handle.net/10261/170490
DOI10.1016/j.diagmicrobio.2012.01.012
ISSN0732-8893
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