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Transcriptome analysis of the brain of the sea bream (Sparus aurata) after exposure to human pharmaceuticals at realistic environmental concentrations

AuthorsHampel, Miriam CSIC ORCID; Blasco, Julián CSIC ORCID ; Babbucci, Massimiliano; Ferraresso, Serena; Bargelloni, Luca; Milan, Massimo
KeywordsHuman pharmaceuticals
Gilthead seabream (Sparus aurata)
cDNA microarray
Expression profiling
Environmental concentration
Issue DateAug-2017
CitationMarine Environmental Research 129: 36-45 (2017)
AbstractHuman pharmaceuticals such as Acetaminophen, Atenolol and Carbamazepine are pseudo persistent aquatic pollutants with yet unknown sub-lethal effects at environmentally relevant concentrations. Gilthead seabream (Sparus aurata) were exposed to Acetaminophen: 31.90 ± 11.07 μg L−1; Atenolol: 0.95 ± 0.38 μg L−1 and Carbamazepine: 6.95 ± 0.13 μg L−1 in a 28 day flow through experiment to (1) determine whether exposure to low concentrations in the μg·L−1 range of the pharmaceuticals alters the brain transcriptome and, (2) identify different expression profiles and treatment specific modes of action and pathways. Despite low exposure concentrations, 411, 7 and 612 differently expressed transcripts were identified in the individual treatments with Acetaminophen, Atenolol and Carbamazepine, respectively. Functional analyses of differentially expressed genes revealed a significant over representation of several biological processes, cellular compartment features and molecular functions for both Acetaminophen and Carbamazepine treatments. Overall, the results obtained in seabream brain suggest similar physiological responses to those observed in humans also at environmental concentrations, as well as the existence of treatment specific processes that may be useful for the development of biomarkers of contamination.
Publisher version (URL)https://doi.org/10.1016/j.marenvres.2017.04.012
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