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Title

Chitosan nanoparticles for combined drug delivery and magnetichyperthermia: From preparation to in vitro studies

AuthorsZamora-Mora, Vanessa ; Fernández-Gutiérrez, Mar ; González, Álvaro; Sanz, Beatriz; San Román, Julio ; Goya, Gerardo F.; Hernández, Rebeca ; Mijangos, Carmen
KeywordsDrug delivery
Cytotoxicity
Uptake
Magnetic hyperthermia
Cancer cells
In vitro studies
Magnetic nanoparticles
Chitosan
Issue Date2017
PublisherElsevier
CitationCarbohydrate Polymers 157: 361-370 (2017)
AbstractChitosan nanoparticles (CSNPs) ionically crosslinked with tripolyphosphate salts (TPP) were employedas nanocarriers in combined drug delivery and magnetic hyperthermia (MH) therapy. To that aim, threedifferent ferrofluid concentrations and a constant 5-fluorouracil (5-FU) concentration were efficientlyencapsulated to yield magnetic CSNPs with core-shell morphology. In vitro experiments using normalcells, fibroblasts (FHB) and cancer cells, human glioblastoma A-172, showed that CSNPs presented a dose-dependent cytotoxicity and that they were successfully uptaken into both cell lines. The application ofa MH treatment in A-172 cells resulted in a cell viability of 67–75% whereas no significant reduction ofcell viability was observed for FHB. However, the A-172 cells showed re-growth populations 4 h after theapplication of the MH treatment when CSNPs were loaded only with ferrofluid. Finally, a combined effectof MH and 5-FU release was observed with the application of a second MH treatment for CSNPs exhibitinga lower amount of released 5-FU. This result demonstrates the potential of CSNPs for the improvementof MH therapies
Publisher version (URL)http://dx.doi.org/10.1016/j.carbpol.2016.09.084
URIhttp://hdl.handle.net/10261/169918
Identifiersdoi: 10.1016/j.carbpol.2016.09.084
issn: 0144-8617
e-issn: 1879-1344
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