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Insights Into Sexual Maturation and Reproduction in the Norway Lobster (Nephrops norvegicus) via in Silico Prediction and Characterization of Neuropeptides and G Protein-coupled Receptors

AutorNguyen, Tuan V.; Rotllant, Guiomar ; Cummins, Scott F.; Elizur, Abigail; Ventura, Tomer
Palabras claveCrustacea
Data mining
Neurohormone
Neuropeptides
Neuropeptidome
GPCRs
Phoenixin
Fecha de publicaciónjul-2018
EditorFrontiers Media
CitaciónFrontiers in Endocrinology
ResumenMultiple biological processes across development and reproduction are modulated by neuropeptides that are predominantly produced and secreted from an animal's central nervous system. In the past few years, advancement of next-generation sequencing technologies has enabled large-scale prediction of putative neuropeptide genes in multiple non-model species, including commercially important decapod crustaceans. In contrast, knowledge of the G protein-coupled receptors (GPCRs), through which neuropeptides act on target cells, is still very limited. In the current study, we have used in silico transcriptome analysis to elucidate genes encoding neuropeptides and GPCRs in the Norway lobster (Nephrops norvegicus), which is one of the most valuable crustaceans in Europe. Fifty-seven neuropeptide precursor-encoding transcripts were detected, including phoenixin, a vertebrate neurohormone that has not been detected in any invertebrate species prior to this study. Neuropeptide gene expression analysis of immature and mature female N. norvegicus, revealed that some reproduction-related neuropeptides are almost exclusively expressed in immature females. In addition, a total of 223 GPCR-encoding transcripts were identified, of which 116 encode GPCR-A (Rhodopsin), 44 encode GPCR-B (Secretin) and 63 encode other GPCRs. Our findings increase the molecular toolbox of neural signaling components in N. norvegicus, allowing for further advances in the fisheries/larvae culture of this species
Descripción16 pages, 8 figures, supplementary material https://doi.org/10.3389/fendo.2018.00430
Versión del editorhttps://doi.org/10.3389/fendo.2018.00430
URIhttp://hdl.handle.net/10261/169777
Identificadoresdoi: 10.3389/fendo.2018.00430
e-issn: 1664-2392
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