English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/169672
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Title

Sensory deprivation in Staphylococcus aureus

AuthorsVillanueva, Maite ; García, Begoña ; Valle Turrillas, Jaione ; Rapún, Beatriz; Ruiz de los Mozos, Igor ; Solano Goñi, Cristina ; Martí, Miguel; Penadés, José R. ; Toledo-Arana, Alejandro ; Lasa, Íñigo
Issue Date6-Feb-2018
PublisherNature Publishing Group
CitationNature Communications 9(1): 523 (2018)
AbstractBacteria use two-component systems (TCSs) to sense and respond to environmental changes. The core genome of the major human pathogen Staphylococcus aureus encodes 16 TCSs, one of which (WalRK) is essential. Here we show that S. aureus can be deprived of its complete sensorial TCS network and still survive under growth arrest conditions similarly to wild-type bacteria. Under replicating conditions, however, the WalRK system is necessary and sufficient to maintain bacterial growth, indicating that sensing through TCSs is mostly dispensable for living under constant environmental conditions. Characterization of S. aureus derivatives containing individual TCSs reveals that each TCS appears to be autonomous and self-sufficient to sense and respond to specific environmental cues, although some level of cross-regulation between non-cognate sensor-response regulator pairs occurs in vivo. This organization, if confirmed in other bacterial species, may provide a general evolutionarily mechanism for flexible bacterial adaptation to life in new niches.
Description12 Páginas, 7 Figuras. Contiene información suplementaria en: http://dx.doi.org/10.1038/s41467-018-02949-y
Publisher version (URL)http://dx.doi.org/10.1038/s41467-018-02949-y
URIhttp://hdl.handle.net/10261/169672
DOI10.1038/s41467-018-02949-y
E-ISSN2041-1723
Appears in Collections:(IBV) Artículos
(IDAB) Artículos
Files in This Item:
File Description SizeFormat 
2018 Nature Communications 6-523.pdf2,62 MBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.