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Título: | Sensory deprivation in Staphylococcus aureus |
Autor: | Villanueva, Maite CSIC ORCID; García, Begoña CSIC ORCID; Valle Turrillas, Jaione CSIC ORCID; Rapún-Araiz, Beatriz CSIC; Ruiz de los Mozos, Igor CSIC ORCID; Solano Goñi, Cristina CSIC ORCID; Martí, Miguel; Penadés, José R. CSIC ORCID; Toledo-Arana, Alejandro CSIC ORCID ; Lasa, Íñigo CSIC ORCID | Fecha de publicación: | 6-feb-2018 | Editor: | Nature Publishing Group | Citación: | Nature Communications 9(1): 523 (2018) | Resumen: | Bacteria use two-component systems (TCSs) to sense and respond to environmental changes. The core genome of the major human pathogen Staphylococcus aureus encodes 16 TCSs, one of which (WalRK) is essential. Here we show that S. aureus can be deprived of its complete sensorial TCS network and still survive under growth arrest conditions similarly to wild-type bacteria. Under replicating conditions, however, the WalRK system is necessary and sufficient to maintain bacterial growth, indicating that sensing through TCSs is mostly dispensable for living under constant environmental conditions. Characterization of S. aureus derivatives containing individual TCSs reveals that each TCS appears to be autonomous and self-sufficient to sense and respond to specific environmental cues, although some level of cross-regulation between non-cognate sensor-response regulator pairs occurs in vivo. This organization, if confirmed in other bacterial species, may provide a general evolutionarily mechanism for flexible bacterial adaptation to life in new niches. | Descripción: | 12 Páginas, 7 Figuras. Contiene información suplementaria en: http://dx.doi.org/10.1038/s41467-018-02949-y | Versión del editor: | http://dx.doi.org/10.1038/s41467-018-02949-y | URI: | http://hdl.handle.net/10261/169672 | DOI: | 10.1038/s41467-018-02949-y | E-ISSN: | 2041-1723 |
Aparece en las colecciones: | (IBV) Artículos (IDAB) Artículos |
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2018 Nature Communications 6-523.pdf | 2,62 MB | Adobe PDF | Visualizar/Abrir |
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