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Título

VRK3

Otros títulosVaccinia-related kinase 3
AutorMoura, David S.; Cantarero, Lara ; Martín-Doncel, Elena ; Campillo-Marcos, Ignacio ; Lazo, Pedro A.
Palabras claveNuclear localization signal
Nuclear envelope
Scaffolding role
Activation loop
Bipartite nuclear localization signal
Fecha de publicación2017
EditorSpringer Nature
CitaciónEncyclopedia of Signaling Molecules: 563-1-1-563-1-4 (2017)
ResumenVRK3 is the most divergent member of the VRK family. It has no kinase activity due to several substitutions in key residues within its catalytic domain. VRK3 is mostly located within the nucleus and appears to play a scaffold role, where it downregulates MAPK signaling and reduces the level of p-ERK by recruiting the VHR phosphatase. In addition VRK3 specifically phosphorylates BAF in Ser4 and induces BAF translocation to cytoplasm. VRK3 expression is cell cycle regulated, reaching its highest levels in interphase.
URIhttp://hdl.handle.net/10261/169604
Identificadoresdoi: 10.1007/978-1-4614-6438-9_563-1
isbn: 978-1-4614-6438-9
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