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| Título: | VRK3 |
Otros títulos: | Vaccinia-related kinase 3 | Autor: | Moura, David S. CSIC ORCID; Cantarero, Lara CSIC ORCID; Martín-Doncel, Elena CSIC ORCID; Campillo-Marcos, Ignacio CSIC ORCID; Lazo, Pedro A. CSIC ORCID | Palabras clave: | Nuclear localization signal Nuclear envelope Scaffolding role Activation loop Bipartite nuclear localization signal |
Fecha de publicación: | 2017 | Editor: | Springer Nature | Citación: | Encyclopedia of Signaling Molecules: 563-1-1-563-1-4 (2017) | Resumen: | VRK3 is the most divergent member of the VRK family. It has no kinase activity due to several substitutions in key residues within its catalytic domain. VRK3 is mostly located within the nucleus and appears to play a scaffold role, where it downregulates MAPK signaling and reduces the level of p-ERK by recruiting the VHR phosphatase. In addition VRK3 specifically phosphorylates BAF in Ser4 and induces BAF translocation to cytoplasm. VRK3 expression is cell cycle regulated, reaching its highest levels in interphase. | URI: | http://hdl.handle.net/10261/169604 | DOI: | 10.1007/978-1-4614-6438-9_563-1 | Identificadores: | doi: 10.1007/978-1-4614-6438-9_563-1 isbn: 978-1-4614-6438-9 |
| Aparece en las colecciones: | (IBMCC) Libros y partes de libros |
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| accesoRestringido.pdf | 15,38 kB | Adobe PDF |  Visualizar/Abrir |
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