English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/169599
Share/Impact:
Statistics
logo share SHARE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Title

Vav family

AuthorsBustelo, Xosé R. ; Dosil, Mercedes
KeywordsSkin papilloma
Serum responsive factor
Vulval epithelium
Subfamily GTPases
Intronic single nucleotide polymorphism
Issue Date2017
PublisherSpringer Nature
CitationEncyclopedia of Signaling Molecules: 1955-2000 (2017)
AbstractVRK2 is a Ser-Thr kinase and has two isoforms, cytosolic and nuclear. The full-length VRK2 cytosolic isoform (A) inhibits MAPK signaling by a direct interaction with the corresponding JIP1 or KSR1 scaffold proteins. As a consequence, high levels of VRK2A inhibit in a dose-dependent manner signals mediated by the TAK1-MKK7-JNK in response to hypoxia or interleukin, and the signal of the ERBB2-RAS-RAF-MEK-ERK pathway. Downregulation of VRK2A relieves this inhibition and allows signal transmission in response to stimuli initiated in receptor-tyrosine kinases (RTK), such as ERBB2. Thus, in breast cancer VRK2A and ERBB2 present an inverse correlation.
URIhttp://hdl.handle.net/10261/169599
Identifiersdoi: 10.1007/978-1-4614-6438-9_513-1
isbn: 978-1-4614-6438-9
Appears in Collections:(IBMCC) Libros y partes de libros
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.