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AuthorsLazo, Pedro A. ; Yunta, M.; Barcia, R.
KeywordsCD53 deficiency
Major histocompatibility complex class
Human leukocyte antigen
CD53 ligation
Homotypic adhesion
Issue Date2017
PublisherSpringer Nature
CitationEncyclopedia of Signaling Molecules: 566-1-1-566-1-7 (2017)
AbstractCD53 is one of the least characterized members of the tetraspanin family. CD53 is integrated in the tetraspanin web, and sends intracellular signals, directly or indirectly via PKC, AKT, and g-glutamyl transpeptidase (GGT7). Its expression can affect cell survival, resistance to apoptosis, and radiation sensitivity. In B-cell development CD53 is a marker of mature B cells. In human B-cell malignancies, the pattern of tetraspanin expression identifies the developmental stage of the corresponding tumors. The pattern of tetraspanins can be used to differentiate B-cell malignancies in an individual patient with several lymphoid tumors.
Identifiersdoi: 10.1007/978-1-4614-6438-9_566-1
isbn: 978-1-4614-6438-9
Appears in Collections:(IBMCC) Libros y partes de libros
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