English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/169531
COMPARTIR / IMPACTO:
Estadísticas
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Título

Dynamics of breaking intermolecular bonds in high-speed force spectroscopy

AutorUhlig, Manuel R.; Amo, Carlos A.; García García, Ricardo
Fecha de publicación5-sep-2018
EditorRoyal Society of Chemistry (Great Britain)
CitaciónNanoscale: Advance Article (2018)
ResumenAtomic force microscope based single-molecule force spectroscopy provides a description of a variety of intermolecular interactions such as those occurring between receptor molecules and their ligands. Advances in force spectroscopy have enabled performing measurements at high-speeds and sub-microsecond resolutions. We report experiments performed on a biotin–avidin system that reveal that the measured force decreases with the loading rate at high rates. This result is at odds with the established Bell–Evans theory that predicts a monotonic increase of the rupture force with the loading rate. We demonstrate that inertial and hydrodynamic forces generated during the breaking of the bond dominate the measured force at high loading rates. We develop a correction factor to incorporate those effects into the Bell–Evans theory. The correction is necessary to obtain accurate values of the intermolecular forces at high speeds.
Versión del editorhttps://doi.org/10.1039/C8NR05715J
URIhttp://hdl.handle.net/10261/169531
DOI10.1039/C8NR05715J
ISSN2040-3364
E-ISSN2040-3372
Aparece en las colecciones: (ICMM) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
NewtonDynamicsHS-SMFS-Nanoscale.pdf Embargado hasta 5 de septiembre de 2019557,87 kBAdobe PDFVista previa
Visualizar/Abrir     Petición de una copia
Mostrar el registro completo
 


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.