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Title

5-Amino-6,7,8,9-Tetrahydrobenzo[b][1,8]Naphthyridin-2(1H)-One: The first Example of a new Family of HuperTacrines for Alzheimer's Disease Therapy

AuthorsBalmori, Alfonso; Chioua, Mourad ; Bellacasa, R. P. de la; Estrada-Tejedor, R.; Ismaili, Lhassane; Marco-Contelles, José ; Borrell, J. I.
KeywordsTacrine
Huperzin
Synthesis
HuperTacrines
Alzheimer’s disease
Issue Date2017
PublisherChemPubSoc Europe
CitationChemistrySelect 2: 2605-2610 (2017)
AbstractIn this communication we have described the synthesis of 2-amino-6-oxo-1,6-dihydropyridine-3-carbonitrile (4), and the preparation of 5-amino-6,7,8,9-tetrahydrobenzo[b][1,8]naphthyridin-2(1H)-one (3 a), a non-hepatotoxic, antioxidant agent, showing moderate, but selective human acetylcholinesterase inhibition.
Publisher version (URL)http://dx.doi.org/10.1002/slct.201700289
URIhttp://hdl.handle.net/10261/169466
Identifiersdoi: 10.1002/slct.201700289
issn: 2365-6549
Appears in Collections:(IQOG) Artículos
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