Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/169348
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Sáez-Freire, María del Mar | - |
dc.contributor.author | Blanco-Gómez, Adrián | - |
dc.contributor.author | Castillo, Sonia | - |
dc.contributor.author | Gómez-Vecino, Aurora | - |
dc.contributor.author | Galvis-Jiménez, Julie Milena | - |
dc.contributor.author | Martín-Seisdedos, Carmen | - |
dc.contributor.author | Isidoro-García, María | - |
dc.contributor.author | Hontecillas-Prieto, Lourdes | - |
dc.contributor.author | García-Cenador, Begoña | - |
dc.contributor.author | García-Criado, Francisco Javier | - |
dc.contributor.author | Patino-Alonso, María Carmen | - |
dc.contributor.author | Galindo-Villardón, Purificación | - |
dc.contributor.author | Mao, Jian-Hua | - |
dc.contributor.author | Prieto, Carlos | - |
dc.contributor.author | Castellanos-Martín, Andrés | - |
dc.contributor.author | Kaderali, Lars | - |
dc.contributor.author | Pérez-Losada, J. | - |
dc.date.accessioned | 2018-09-03T10:47:46Z | - |
dc.date.available | 2018-09-03T10:47:46Z | - |
dc.date.issued | 2018 | - |
dc.identifier | doi: 10.1016/j.dib.2018.03.132 | - |
dc.identifier | e-issn: 2352-3409 | - |
dc.identifier.citation | Data in Brief 18: 1172-1184 (2018) | - |
dc.identifier.uri | http://hdl.handle.net/10261/169348 | - |
dc.description.abstract | The data presented in this article are related to the research paper entitled “The biological age linked to oxidative stress modifies breast cancer aggressiveness” (M.M. Sáez-Freire, A. Blanco-Gómez, S. Castillo-Lluva, A. Gómez-Vecino, J.M. Galvis-Jiménez, C. Martín-Seisdedos, M. Isidoro-García, L. Hontecillas-Prieto, M.B. García-Cenador, F.J. García-Criado, M.C. Patino-Alonso, P. Galindo-Villardón, J.H. Mao, C. Prieto, A. Castellanos-Martín, L. Kaderali, J. Pérez-Losada). The data shown were obtained from a population of transgenic mice, MMTV-Erbb2/Neu, with different susceptibility to breast cancer and a mixed genetic background generated by backcrossing. It was observed that the aggressiveness of breast cancer negatively correlates with age, being lower in chronologically old mice, similar to what occurs in humans. Given that oxidative stress is associated with tumour susceptibility and the degree of aging, the association between the aggressiveness of breast cancer and multiple intermediate phenotypes directly or indirectly related to oxidative stress was studied. Using a mathematical model, we defined biological age and the degree of aging as the difference between biological and chronological ages. As a result, we observed that biologically old mice predominated among those that developed the disease early on, that is, those that were chronologically young. We then identified the specific and common genetic components of Quantitative Trait loci or QTL associated with different evolution of breast cancer, the intermediate phenotypes related to oxidative stress studied, the biological age and the degree of aging. Lastly, we showed that the expression pattern in the livers of biologically old mice were enriched in signalling pathways related to inflammation and response to infections; whereas the biologically young mice exhibited enriched pathways related to mitochondrial activity. For the explanation and discussion of these data refer to the research article cited above. | - |
dc.description.sponsorship | JPL was partially supported by FEDER and the MICINN (SAF2014-56989-R, SAF2017-88854R), the Instituto de Salud Carlos III (PIE14/00066), >Proyectos Integrados IBSAL 2015> (IBY15/00003), the Sandra Ibarra Foundation>de Solidaridad Frente al Cáncer> Foundation and >We can be heroes> Foundation. JHM was supported by the National Institutes of Health, a National Cancer Institute grant (R01 CA116481), and the Low-Dose Scientific Focus Area, Office of Biological & Environmental Research, US Department of Energy (DE-AC02−05CH11231). | - |
dc.publisher | Elsevier | - |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2014-56989-R | - |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2017-88854-R | - |
dc.relation.isversionof | Publisher's version | - |
dc.rights | openAccess | - |
dc.title | Supplementary data for the biological age linked to oxidative stress modifies breast cancer aggressiveness | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1016/j.dib.2018.03.132 | - |
dc.relation.publisherversion | https://doi.org/10.1016/j.dib.2018.03.132 | - |
dc.date.updated | 2018-09-03T10:47:47Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.rights.license | http://creativecommons.org/licenses/by/4.0/ | - |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | - |
dc.contributor.funder | National Cancer Institute (US) | - |
dc.contributor.funder | Fundación Sandra Ibarra - Solidaridad Frente al Cáncer | - |
dc.contributor.funder | Department of Energy (US) | - |
dc.contributor.funder | Instituto de Salud Carlos III | - |
dc.contributor.funder | European Commission | - |
dc.contributor.funder | National Institutes of Health (US) | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100007649 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004587 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004837 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/100000002 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/100000015 | es_ES |
dc.identifier.pmid | 29900291 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
Aparece en las colecciones: | (IBMCC) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
suppaggress.pdf | 3,84 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
1
checked on 17-abr-2024
SCOPUSTM
Citations
1
checked on 17-abr-2024
WEB OF SCIENCETM
Citations
1
checked on 23-ene-2024
Page view(s)
379
checked on 23-abr-2024
Download(s)
230
checked on 23-abr-2024