Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/169319
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Larriba, E. | es_ES |
dc.contributor.author | Del Mazo, Jesús | es_ES |
dc.date.accessioned | 2018-08-31T12:09:14Z | - |
dc.date.available | 2018-08-31T12:09:14Z | - |
dc.date.issued | 2018-08-27 | - |
dc.identifier.citation | Scientific Reports 8:12832 (2018) | es_ES |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/10261/169319 | - |
dc.description | 13 p.-7 fig.-5 tab. | es_ES |
dc.description.abstract | Piwi-interacting RNAs (piRNAs) are a subclass of the small non-coding RNAs (sncRNAs). Their main reported function was to exert control over transposable elements (TEs) in mammalian germline. In this study undertaking a deeper bioinformatics analysis of piRNAs present in mouse oocytes, sperm cells and zygotes, we first elaborated a new piRNA database based on sequences identified as piRNAs by immunoprecipitation with PIWI proteins. Our bioinformatics analysis revealed that, at least in gametes and zygotes, piRNAs could encompass multifunctional cell-dependent regulatory molecules. Indeed, genome analysis of the piRNA mapping density (reads/kb) evidenced in all samples an enrichment of intron-derived piRNAs. Further, piRNA population was classified into sequences not associated to TEs or repeats (NRapiRNAs) and associated to repetitive genome elements (RapiRNAs). In oocytes most of the NRapiRNAs mapped to the 5′UTRs of coding mRNAs, while higher proportion of NRapiRNAs was detected in sperm cells associated to the 3′UTRs of mRNAs. This piRNA complementarity to mRNA UTRs suggests key post-transcriptional regulatory roles over mRNAs such as those encoding MHC genes. In addition, a striking association of RapiRNA with long non-coding RNAs (lncRNAs) was identified. piRNAs associated with relevant lncRNAs such as: Rab26os and GAS5 and key mRNAs, were particularly assessed. | es_ES |
dc.description.sponsorship | This research was supported by grants from the Ministerio de Ciencia Innovación y Universidades (BFU2013-42164-R and BFU2017-87095-R), Spain. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Nature Publishing Group | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2013-42164-R | es_ES |
dc.relation | BFU2017-87095-R/AEI/10.13039/501100011033 | - |
dc.relation | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/BFU2017-87095-R | es_ES |
dc.relation.isversionof | Publisher's version | es_ES |
dc.rights | openAccess | es_ES |
dc.title | An integrative piRNA analysis of mouse gametes and zygotes reveals new potential origins and gene regulatory roles | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1038/s41598-018-31032-1 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | https://doi.org/10.1038/s41598-018-31032-1 | es_ES |
dc.identifier.e-issn | 1932-6203 | - |
dc.rights.license | https://creativecommons.org/licenses/by/4.0/ | es_ES |
dc.contributor.funder | Agencia Estatal de Investigación (España) | - |
dc.contributor.funder | Ministerio de Ciencia, Innovación y Universidades (España) | es_ES |
dc.relation.csic | Sí | es_ES |
oprm.item.hasRevision | no ko 0 false | * |
dc.identifier.funder | http://dx.doi.org/10.13039/501100011033 | es_ES |
dc.contributor.orcid | Larriba, E. [0000-0001-8838-4974] | es_ES |
dc.contributor.orcid | Del Mazo, Jesús [0000-0003-3269-3895] | es_ES |
dc.identifier.pmid | 30150632 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
item.cerifentitytype | Publications | - |
item.openairetype | artículo | - |
item.languageiso639-1 | en | - |
item.grantfulltext | open | - |
Aparece en las colecciones: | (CIB) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Plos_One 2018.pdf | Artículo principal | 3,63 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
10
checked on 22-mar-2024
SCOPUSTM
Citations
15
checked on 15-abr-2024
WEB OF SCIENCETM
Citations
14
checked on 29-feb-2024
Page view(s)
331
checked on 17-abr-2024
Download(s)
233
checked on 17-abr-2024