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Characterizing patients with multiple chromosomal aberrations detected by FISH in chronic lymphocytic leukemia

AutorGonzález-Gascón y Marín, Isabel; Hernández-Sánchez, María; Rodríguez-Vicente, Ana Eugenia; Puiggros, Anna; Collado, Rosa; Luño, Elisa; González, María-Teresa; Ruiz-Xivillé, Neus; Ortega, Margarita; Gimeno, Eva; Muñoz-Novas, Carolina; Infante, María-Stefania; Delgado, Julio; Vargas, Mª Teresa; González, Marcos ; Bosch, Francesc; Espinet, Blanca; Hernández, Jesús M. ; Hernández, José Ángel
Palabras clavePrognosis
Multiple abnormalities
Chronic lymphocytic leukemia
Fluorescence in-situ hybridization
Fecha de publicación2018
EditorTaylor & Francis
CitaciónLeukemia and Lymphoma 59(3): 633-642 (2018)
ResumenWe analyzed the features of chronic lymphocytic leukemia (CLL) with multiple abnormalities (MA) detected by FISH. A local database including 2095 CLL cases was used and 323 with MA (15.4%) were selected. MA was defined by the presence of two or more alterations (deletions of 13q14 (13q-), 11q22 (11q-), 17p13 (17p-) or trisomy 12 (+12)). The combination of 13q- with 11q- and 13q- with 17p-, accounted for 58.2% of the series, in contrast to 11q- with 17p- (3.7%). Patients carrying MA since diagnosis presented a short time to first therapy(TTFT) (27 months) and overall survival (OS) (76 months). The combinations including 17p- had a shorter OS (58 months) than the ones without 17p- (not reached, p =.002). Patients with a complex-FISH were the ones with worse OS (34 months). MA imply poor prognosis when they emerge at diagnosis, probably due to the high incidence of bad prognosis markers, which may be a reflection of a more complex karyotype.
DescripciónOn behalf of Grupo Español de Leucemia Linfática Crónica (GELLC) and Grupo Cooperativo Español de Citogenética Hematológica (GCECGH).
URIhttp://hdl.handle.net/10261/169316
Identificadoresdoi: 10.1080/10428194.2017.1349901
e-issn: 1029-2403
issn: 1042-8194
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