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Absence of spontaneous response improvement beyond day +100 after autologous stem cell transplantation in multiple myeloma

AutorFernández de Larrea, Carlos; Dávila, Julio; Isola, I.; Ocio, Enrique M. ; Rosiñol, Laura; García-Sanz, Ramón; Cibeira, M.T.; Tovar, N.; Rovira, M.; Mateos, Maria Victoria; Miguel, J. S.; Bladé, Joan
Fecha de publicación2017
EditorNature Publishing Group
CitaciónBone Marrow Transplantation 52(4): 567-569 (2017)
ResumenThe response evaluation after autologous stem-cell transplantation (ASCT) is usually performed at day +100 in patients with multiple myeloma (MM). A recent report suggests that improvement in the response can be observed beyond day +100. The aim of the present study has been to evaluate the rate of improved response and outcome beyond day +100 after ASCT, with and without maintenance therapy. One hundred and forty-four patients who underwent single ASCT with chemosensitive disease and achieved less than CR at day 100 post ASCT were evaluated. Seventy-four patients (51.4%) did not receive any maintenance with only one of them showing an upgrade in the response. The remaining 70 patients (48.6%) received maintenance therapy; eleven of them (15.7%) improved their response beyond day +100. The outcome of these patients was better than those who did not upgrade their response in both progression-free survival and overall survival (P=0.019 and P=0.031, respectively). In conclusion, the improvement in response beyond day +100 after ASCT in patients not receiving any therapy is exceedingly rare. A minority of patients receiving maintenance therapy after ASCT upgrades their response and this finding is associated with better outcome.
URIhttp://hdl.handle.net/10261/169285
Identificadoresdoi: 10.1038/bmt.2016.299
e-issn: 1476-5365
issn: 0268-3369
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