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Chronic lymphocytic leukemia with isochromosome 17q: An aggressive subgroup associated with TP53 mutations and complex karyotypes

AuthorsCollado, Rosa; Puiggros, Anna; López-Guerrero, José Antonio ; Calasanz, Mª Jose; Larrayoz, Mª José; Ivars, David; García-Casado, Zaida; Abella, Eugènia; Orero, Mª Teresa; Talavera, Elisabet; Oliveira, Ana Carla; Hernández, Jesús M. ; Hernández-Sánchez, María; Luño, Elisa; Valiente, Alberto; Grau, Javier; Portal, Inmaculada; Gardella, Santiago; Camino Salgado, Ana; Giménez, Teresa; Ardanaz, María Teresa; Campeny, Andrea; Hernández, José Julio; Álvarez, Sara; Espinet, Blanca; Carbonell, Félix
KeywordsComplex karyotype
Isochromosome 17q
Chronic lymphocytic leukemia
Issue Date2017
CitationCancer Letters 409: 42-48 (2017)
AbstractAlthough i(17q) [i(17q)] is frequently detected in hematological malignancies, few studies have assessed its clinical role in chronic lymphocytic leukemia (CLL). We recruited a cohort of 22 CLL patients with i(17q) and described their biological characteristics, mutational status of the genes TP53 and IGHV and genomic complexity. Furthermore, we analyzed the impact of the type of cytogenetic anomaly bearing the TP53 defect on the outcome of CLL patients and compared the progression-free survival (PFS) and overall survival (OS) of i(17q) cases with those of a group of 38 CLL patients harboring other 17p aberrations. We detected IGHV somatic hypermutation in all assessed patients, and TP53 mutations were observed in 71.4% of the cases. Patients with i(17q) were more commonly associated with complex karyotypes (CK) and tended to have a poorer OS than patients with other anomalies affecting 17p13 (median OS, 44 vs 120 months, P = 0.084). Regarding chromosomal alterations, significant differences in the median OS were found among groups (P = 0.044). In conclusion, our findings provide new insights regarding i(17q) in CLL and show a subgroup with adverse prognostic features.
Identifiersdoi: 10.1016/j.canlet.2017.08.041
e-issn: 1872-7980
issn: 0304-3835
Appears in Collections:(IBMCC) Artículos
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