English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/169242
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:

Title

Chronic lymphocytic leukemia with isochromosome 17q: An aggressive subgroup associated with TP53 mutations and complex karyotypes

AuthorsCollado, Rosa; Puiggros, Anna; López-Guerrero, José Antonio ; Calasanz, Mª Jose; Larrayoz, Mª José; Ivars, David; García-Casado, Zaida; Abella, Eugènia; Orero, Mª Teresa; Talavera, Elisabet; Oliveira, Ana Carla; Hernández, Jesús M. ; Hernández-Sánchez, María; Luño, Elisa; Valiente, Alberto; Grau, Javier; Portal, Inmaculada; Gardella, Santiago; Camino Salgado, Ana; Giménez, Teresa; Ardanaz, María Teresa; Campeny, Andrea; Hernández, José Julio; Álvarez, Sara; Espinet, Blanca; Carbonell, Félix
KeywordsComplex karyotype
Isochromosome 17q
Chronic lymphocytic leukemia
Survival
IGHV
TP53
Issue Date2017
PublisherElsevier
CitationCancer Letters 409: 42-48 (2017)
AbstractAlthough i(17q) [i(17q)] is frequently detected in hematological malignancies, few studies have assessed its clinical role in chronic lymphocytic leukemia (CLL). We recruited a cohort of 22 CLL patients with i(17q) and described their biological characteristics, mutational status of the genes TP53 and IGHV and genomic complexity. Furthermore, we analyzed the impact of the type of cytogenetic anomaly bearing the TP53 defect on the outcome of CLL patients and compared the progression-free survival (PFS) and overall survival (OS) of i(17q) cases with those of a group of 38 CLL patients harboring other 17p aberrations. We detected IGHV somatic hypermutation in all assessed patients, and TP53 mutations were observed in 71.4% of the cases. Patients with i(17q) were more commonly associated with complex karyotypes (CK) and tended to have a poorer OS than patients with other anomalies affecting 17p13 (median OS, 44 vs 120 months, P = 0.084). Regarding chromosomal alterations, significant differences in the median OS were found among groups (P = 0.044). In conclusion, our findings provide new insights regarding i(17q) in CLL and show a subgroup with adverse prognostic features.
URIhttp://hdl.handle.net/10261/169242
DOIhttp://dx.doi.org/10.1016/j.canlet.2017.08.041
Identifiersdoi: 10.1016/j.canlet.2017.08.041
e-issn: 1872-7980
issn: 0304-3835
Appears in Collections:(IBMCC) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.