Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/169201
COMPARTIR / EXPORTAR:
logo share SHARE logo core CORE BASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE

Invitar a revisión por pares abierta
Campo DC Valor Lengua/Idioma
dc.contributor.authorZyuzin, Mikhail V.-
dc.contributor.authorDíez, Paula-
dc.contributor.authorGoldsmith, Mier-
dc.contributor.authorCarregal-Romero, Susana-
dc.contributor.authorTeodosio, Cristina-
dc.contributor.authorRejman, Joanna-
dc.contributor.authorFeliu, Neus-
dc.contributor.authorEscudero, A.-
dc.contributor.authorAlmendral Parra, María Jesús-
dc.contributor.authorLinne, Uwe-
dc.contributor.authorPeer, Dan-
dc.contributor.authorFuentes, Manuel-
dc.contributor.authorParak, Wolfgang J.-
dc.date.accessioned2018-08-28T09:41:20Z-
dc.date.available2018-08-28T09:41:20Z-
dc.date.issued2017-
dc.identifierdoi: 10.1021/acs.bioconjchem.6b00657-
dc.identifiere-issn: 1520-4812-
dc.identifierissn: 1043-1802-
dc.identifier.citationBioconjugate Chemistry 28(2): 556-564 (2017)-
dc.identifier.urihttp://hdl.handle.net/10261/169201-
dc.description.abstractThe immunocompability of polyelectrolyte capsules synthesized by layer-by-layer deposition has been investigated. Capsules of different architecture and composed of either non-degradable or biodegradable polymers, with either positively or negatively charged outer surface, and with micrometer size, have been used, and the capsule uptake by different cell lines has been studied and quantified. Immunocompatibility studies were performed with peripheral blood mononuclear cells (PBMCs). Data demonstrate that incubation with capsules, at concentrations relevant for practical applications, did not result in a reduced viability of cells, as it did not show an increased apoptosis. Presence of capsules also did not result in an increased expression of TNF-α, as detected with antibody staining, as well as at mRNA level. It also did not result in increased expression of IL-6, as detected at mRNA level. These results indicate that the polyelectrolyte capsules used in this study are immunocompatible.-
dc.description.sponsorshipThis work was supported by the German Research Foundation (DFG grant PA 794/21-1 to W.J.P.) and the Sino-German cooperative project No. GZ 905 from the Sino German Center. We gratefully acknowledge financial support from the Carlos III Health Institute of Spain (ISCIII, FIS PI14/01538), Fondos FEDER (EU), Junta Castilla-Leon BIO/SA07/15, Fundacion Solorzano FS/23-2015. The Proteomics Units belongs to ProteoRed, PRB2-ISCIII, supported by grant PT13/0001. P.D. is supported by a JCYL-EDU/346/2013 PhD scholarship. D.P. acknowledges the FTA: Nanomedicines for Personalized Theranostics of the Israeli National Nanotechnology Initiative and the Leona M. and Harry B. Helmsley Nanotechnology Research Fund. A.E. acknowledges Junta de Andalucía (Spain) for a Talentia Postdoc Fellowship, cofinanced by the European Union Seventh Framework Programme, grant agreement no 267226.-
dc.publisherAmerican Chemical Society-
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/267226-
dc.rightsclosedAccess-
dc.titleComprehensive and systematic analysis of the immunocompatibility of polyelectrolyte capsules-
dc.typeartículo-
dc.identifier.doi10.1021/acs.bioconjchem.6b00657-
dc.date.updated2018-08-28T09:42:40Z-
dc.description.versionPeer Reviewed-
dc.language.rfc3066eng-
dc.contributor.funderGerman Research Foundation-
dc.contributor.funderInstituto de Salud Carlos III-
dc.contributor.funderFundación Memoria de D. Samuel Solorzano Barruso-
dc.contributor.funderJunta de Castilla y León-
dc.contributor.funderIsrael National Nanotechnology Initiative-
dc.contributor.funderJunta de Andalucía-
dc.contributor.funderEuropean Commission-
dc.relation.csic-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100001659es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100004587es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100014180es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100011011es_ES
dc.identifier.pmid28040889-
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
Aparece en las colecciones: (IBMCC) Artículos
(ICMS) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato
accesoRestringido.pdf15,38 kBAdobe PDFVista previa
Visualizar/Abrir
Show simple item record

CORE Recommender

PubMed Central
Citations

9
checked on 28-mar-2024

SCOPUSTM   
Citations

38
checked on 22-mar-2024

WEB OF SCIENCETM
Citations

34
checked on 29-feb-2024

Page view(s)

403
checked on 29-mar-2024

Download(s)

123
checked on 29-mar-2024

Google ScholarTM

Check

Altmetric

Altmetric


Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.