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dc.contributor.authorMatarraz, Sergio-
dc.contributor.authorAlmeida, Julia-
dc.contributor.authorFlores-Montero, Juan-
dc.contributor.authorLécrevisse, Quentin-
dc.contributor.authorGuerri, Valentina-
dc.contributor.authorLópez, Antonio-
dc.contributor.authorBarrena, Susana-
dc.contributor.authorVelden, Vincent H. J. van der-
dc.contributor.authorMarvelde, Jeroen G. te-
dc.contributor.authorDongen, J. J. M. van-
dc.contributor.authorOrfao, Alberto-
dc.date.accessioned2018-08-27T09:47:20Z-
dc.date.available2018-08-27T09:47:20Z-
dc.date.issued2017-
dc.identifierdoi: 10.1002/cyto.b.21219-
dc.identifiere-issn: 1552-4957-
dc.identifierissn: 1552-4949-
dc.identifier.citationCytometry Part B: Clinical Cytometry 92(3): 218-227 (2017)-
dc.identifier.urihttp://hdl.handle.net/10261/169165-
dc.description.abstractDespite diagnostic criteria are currently available for the distinct subtypes of monocytic-lineage neoplasias, a number of partially overlapping features still remain evident, which may hamper their differential diagnosis. An accurate identification and characterization of monocytic cells is of major relevance for the diagnosis and classification of these neoplasias. In this regard, as compared to other conventional techniques, flow cytometry has shown the highest sensitivity for detection of early monocytic commitment of (normal and neoplastic) bone marrow CD34 hematopoietic precursors as well as of monocytic aberrations and maturation blockades, which are frequently associated with clonal myeloid disorders. In the present paper we provide basic principles and criteria for multiparameter flow cytometry identification and characterization of bone marrow monocytic cells that contribute to an improved diagnostic and classification of monocytic lineage-associated acute leukemias in clinical settings, particularly when using the EuroFlow antibody panels.-
dc.description.sponsorshipGrant sponsor: Fundacion Cientıfica de la Asociacion Espanola Contra el Cancer (AECC), Consejerıa de Sanidad; Grant sponsor: Gerencia Regional de Salud de Castilla y Leon (SACYL); Grant number: BIO/SA24/13; Grant sponsors: Fundacion Samuel Solorzano Barruso (University of Salamanca, Spain), BlackSwan Project from the International Myeloma Foundation, North Hollywood, CA, United States of America; Grant sponsor: Cooperative Cancer Research Thematic Network (RTICC); Grant number: RD12/0036/0048; Grant sponsor: Instituto de Salud Carlos III-FEDER, Ministerio de Economia y Competitividad, Madrid, Spain.-
dc.publisherJohn Wiley & Sons-
dc.rightsclosedAccess-
dc.subjectAcute leukemia-
dc.subjectMonocytes-
dc.subjectFlow cytometry-
dc.titleIntroduction to the diagnosis and classification of monocytic-lineage leukemias by flow cytometry-
dc.typeArtículo-
dc.date.updated2018-08-27T09:47:24Z-
dc.description.versionPeer Reviewed-
dc.language.rfc3066eng-
dc.contributor.funderInstituto de Salud Carlos III-
dc.contributor.funderMinisterio de Economía y Competitividad (España)-
dc.contributor.funderFundación Científica Asociación Española Contra el Cáncer-
dc.contributor.funderJunta de Castilla y León-
dc.contributor.funderFundación Memoria de D. Samuel Solorzano Barruso-
dc.contributor.funderInternational Myeloma Foundation-
dc.contributor.funderRed Temática de Investigación Cooperativa en Cáncer (España)-
dc.relation.csic-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100004587es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003329es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100002704es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/100003887es_ES
dc.identifier.pmid26282340-
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