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http://hdl.handle.net/10261/169109
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dc.contributor.author | Riccardi, Claudia | es_ES |
dc.contributor.author | Fàbrega, Carme | es_ES |
dc.contributor.author | Grijalvo, Santiago | es_ES |
dc.contributor.author | Vitiello, Giuseppe | es_ES |
dc.contributor.author | D'Errico, Geradino | es_ES |
dc.contributor.author | Eritja Casadellà, Ramón | es_ES |
dc.contributor.author | Montesarchio, Daniela | es_ES |
dc.date.accessioned | 2018-08-24T06:40:59Z | - |
dc.date.available | 2018-08-24T06:40:59Z | - |
dc.date.issued | 2018-07-27 | - |
dc.identifier.citation | Journal of Materials Chemistry B 6: 5368-5384 (2018) | es_ES |
dc.identifier.uri | http://hdl.handle.net/10261/169109 | - |
dc.description.abstract | Niosomes are self-assembled vesicles made up of single chain non-ionic surfactants combined with appropriate amounts of cholesterol or other lipids, exploited as carriers for hydrophilic or lipophilic drugs. Compared to liposomes, niosomes are typically more stable, less expensive and, being generally obtained from synthetic surfactants, more easily derivatizable, providing vesicular structures with a higher versatility and chemical diversity. Herein, we investigated the physico-chemical and biological properties of niosomes loaded with two active ingredients, i.e. the nucleolipidic Ru(III)-complex HoThyRu, selected as an anticancer agent, and the nucleolin-targeting AS1411 aptamer, allowing selective recognition of cancer cells. The morphology, average size, zeta potential, electrophoretic mobility, and stability over time of the functionalized niosomes were analyzed using different biophysical techniques. These formulations, tested on both cancer and normal cells, showed promising antiproliferative activity on HeLa cells, with a higher efficacy associated with the nanosystems containing both AS1411 and HoThyRu with respect to the controls. In all the tested cell lines, AS1411 proved to markedly enhance the bioactivity of the Ru(III)-containing niosomes. | es_ES |
dc.description.sponsorship | We are deeply grateful to dr. Rocco Di Girolamo, from the Department of Chemical Sciences, University of Naples Federico II, for his precious contribution for the TEM images acquisition. This work was supported by the Italian Association for Cancer Research (AIRC) (IG2015 n. 17037 to D. M.). C. R. thanks “Programma di scambi internazionali tra l'Università degli Studi di Napoli Federico II ed Università ed Istituti di ricerca stranieri per la mobilità di breve durata di docenti, ricercatori e studiosi”. Financial support by the Spanish Ministerio de Ciencia e Innovación (MICINN) (Project CTQ2014-52588-R and CTQ2017-84415-R) and Generalitat de Catalunya (2017SGR114) are gratefully acknowledged. CIBER-BBN is an initiative funded by the Instituto de Salud Carlos III with assistance from the European Regional Development Fund. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Royal Society of Chemistry (UK) | es_ES |
dc.relation.isversionof | Postprint | es_ES |
dc.rights | openAccess | en_EN |
dc.subject | Niosomes | es_ES |
dc.subject | AS1411 | es_ES |
dc.title | AS1411-decorated niosomes as effective nanocarriers for Ru(III)-based drugs in anticancer strategies | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1039/C8TB01563E | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | 10.1039/C8TB01563E | es_ES |
dc.embargo.terms | 2019-07-27 | es_ES |
dc.relation.csic | Sí | es_ES |
oprm.item.hasRevision | no ko 0 false | * |
dc.identifier.pmid | Sí | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
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AS1411-decorated niosomes as effective.pdf | 2,24 MB | Adobe PDF | Visualizar/Abrir |
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