English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/169015
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:


Marine collagen/apatite composite scaffolds envisaging hard tissue applications

AuthorsDiogo, Gabriela S.; López-Senra, E. ; Pirraco, Rogério P.; Canadas, Raphael F.; Fernandes, Emanuel M.; Serra, Julia; Pérez Martín, Ricardo Isaac ; González Sotelo, Carmen ; Marques, Alexandra P.; González, Pio; Moreira-Silva, Joana; Silva, Tiago H.; Reis, Rui L.
KeywordsMarine biomaterials
Bone tissue engineering
Shark by-products
Issue Date3-Aug-2018
PublisherMultidisciplinary Digital Publishing Institute
CitationMarine Drugs 16(8): 269 (2018)
AbstractThe high prevalence of bone defects has become a worldwide problem. Despite the significant amount of research on the subject, the available therapeutic solutions lack efficiency. Autografts, the most commonly used approaches to treat bone defects, have limitations such as donor site morbidity, pain and lack of donor site. Marine resources emerge as an attractive alternative to extract bioactive compounds for further use in bone tissue-engineering approaches. On one hand they can be isolated from by-products, at low cost, creating value from products that are considered waste for the fish transformation industry. One the other hand, religious constraints will be avoided. We isolated two marine origin materials, collagen from shark skin (Prionace glauca) and calcium phosphates from the teeth of two different shark species (Prionace glauca and Isurus oxyrinchus), and further proposed to mix them to produce 3D composite structures for hard tissue applications. Two crosslinking agents, 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride/N-Hydroxysuccinimide (EDC/NHS) and hexamethylene diisocyanate (HMDI), were tested to enhance the scaffolds’ properties, with EDC/NHS resulting in better properties. The characterization of the structures showed that the developed composites could support attachment and proliferation of osteoblast-like cells. A promising scaffold for the engineering of bone tissue is thus proposed, based on a strategy of marine by-products valorisation.
Publisher version (URL)https://doi.org/10.3390/md16080269
Appears in Collections:(IIM) Artículos
Files in This Item:
File Description SizeFormat 
marinedrugs-16-00269-v2.pdf5,38 MBAdobe PDFThumbnail
Show full item record
Review this work

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.