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Feminization of wild carp, Cyprinus carpionext term, in a polluted environment: plasma steroid hormones, gonadal morphology and xenobiotic metabolizing system
|Autor:||Solé, Montserrat ; Raldúa, Demetrio; Piferrer, Francesc ; Barceló, Damià; Porte Visa, Cinta|
Sewage treatment works
|Fecha de publicación:||oct-2003|
|Citación:||Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 136(2): 145-156 (2003)|
|Resumen:||Wild carp, previous termCyprinus carpionext term, were sampled in January and March 2000 in a section of the Anoia River (NE Spain) known to be polluted by estrogenic compounds. At each sampling time, three groups were distinguished: (1) apparently normal males; (2) apparently normal females; and (3) affected fish. The latter were characterized by the simultaneous development of male and female tissue in their gonads at a macroscopical level (six out of 31 fish sampled at this particular point), or testicular atrophy (three out of 31). Plasmatic and hepatic vitellogenin (VTG) levels and plasma testosterone (T) and estradiol (E2) were measured to observe the particular estrogenic response of the affected fish. Moreover, the response in the xenobiotic metabolizing capacity in liver was tested. This involved the analysis of mixed function oxygenase (MFO) system such as: total cytochrome P450 content, NAD(P)H cytochrome c reductases and the associated CYP1A1, EROD activity. Also, glutathione S-transferase (GST) and UDP-glucuronosyltransferase (UDPGT) as detoxifying enzymes were measured. Our results showed: (1) a highly variable VTG content in all fish groups; (2) an increase in sex hormones content in March for the female group; and (3) an enhanced xenobiotics metabolism in the affected fish group, measured as total cytochrome P450, EROD activity in the January survey and cytosolic GST in March. The observed increase in VTG, sex hormones and in most of the enzymatic activities from January to March that could also be attributed to higher water temperature.|
|Descripción:||12 pages, 3 tables.-- PMID: 14559296 [PubMed].|
|Versión del editor:||http://dx.doi.org/10.1016/S1532-0456(03)00192-3|
|Aparece en las colecciones:||(ICM) Artículos|
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