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Título

Cloning of the promoter from the gonadal aromatase gene of the European sea bass and identification of single nucleotide polymorphisms

AutorGalay-Burgos, Malyka; Gealy, Claire; Navarro-Martín, Laia ; Piferrer, Francesc ; Zanuy, Silvia ; Sweeney, Glen E.
Palabras claveAromatase
Promoter
Sea bass
Gonadal
SF-1
Sex differentiation
Gene expression
SNPs
Fecha de publicación30-abr-2006
EditorElsevier
CitaciónComparative Biochemistry and Physiology Part A 145(1): 47-53 (2006)
ResumenAromatase contributes to sex differentiation by catalysing the conversion of androgens into estrogens. We have cloned the promoter of the gonadal aromatase gene from the sea bass, Dicentrarchus labrax, a species whose farming is complicated by male-skewed sex ratios. The promoter shows a conserved binding site for SF-1 as well as two cAMP response elements (CREs) and putative binding sites for transcription factors belonging to the Sox and forkhead families. Analysis of promoter sequences from individual fish suggests the presence of three promoter alleles that arise due to three single nucleotide polymorphisms (SNPs) in linkage disequilibrium.
Descripción7 pages, 3 figures.-- PMID: 16782377 [PubMed].-- Printed version published Sep 2006.
Versión del editorhttp://dx.doi.org/10.1016/j.cbpa.2006.04.028
URIhttp://hdl.handle.net/10261/16885
DOI10.1016/j.cbpa.2006.04.028
ISSN1095-6433
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