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http://hdl.handle.net/10261/168807
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Puig-Kröger, Amaya | es_ES |
dc.contributor.author | López-Rodríguez, Cristina | es_ES |
dc.contributor.author | Relloso, Miguel | es_ES |
dc.contributor.author | Sánchez-Elsner, Tilman | es_ES |
dc.contributor.author | Nueda, Arsenio | es_ES |
dc.contributor.author | Muñoz, Eduardo | es_ES |
dc.contributor.author | Bernabéu, Carmelo | es_ES |
dc.contributor.author | Corbí, Angel L. | es_ES |
dc.date.accessioned | 2018-08-17T09:16:51Z | - |
dc.date.available | 2018-08-17T09:16:51Z | - |
dc.date.issued | 2000-09-15 | - |
dc.identifier.citation | J Biol Chem 275(37):28507-12 (2000) | es_ES |
dc.identifier.issn | 0021-9258 | - |
dc.identifier.uri | http://hdl.handle.net/10261/168807 | - |
dc.description | 7 p.-7 fig.1 tab. | es_ES |
dc.description.abstract | The CD11a/CD18 leukocyte integrin (LFA-1; also known as alphaL/beta2) mediates leukocyte transendothelial migration during immune and inflammatory responses and participates in lymphoma metastasis. CD11a/CD18 leukocyte-restricted expression is controlled by the CD11a gene promoter, which confers tissue-specific expression to reporter genes in vitro and in vivo. DNase I protection analysis of the CD11a proximal gene promoter revealed DNA-protein interactions centered at position -110 (CD11a-110). Disruption of CD11a-110 reduced CD11a promoter activity in a cell type-specific manner, as it reduced its activity by 70% in Jurkat lymphoid cells, whereas the effect was considerably lower in K562 and HepG2 cells. Electrophoretic mobility shift assays showed evidence of cell type-specific differences in CD11a-110 binding and indicated its specific recognition by members of the polyomavirus enhancer-binding protein 2/core binding factor (CBF)/acute myeloid leukemia (AML) family of transcription factors. AML1B/CBFbeta transactivated the CD11a promoter, with AML1B/CBFbeta-mediated transactivation being completely dependent on the integrity of the CD11a-110 element. Therefore, CBF/AML factors play a role in the cell type-restricted transcription of the CD11a integrin gene through recognition of CD11a-110. The involvement of CBF/AML factors in CD11a expression raises the possibility that CD11a/CD18 expression might be deregulated in acute myeloid and B-lineage acute lymphoblastic leukemias, thus contributing to their altered adhesion and metastatic potential. | es_ES |
dc.description.sponsorship | This work was supported by Comision Interministerial de Cienca Y Tecnologia (CICYT) Grant SAF98/0068 and Comunidad Autónoma de Madrid Grant 08.2/0035.1/99 (to A. L. C.) and by CICYT Grant SAF97/0034 (to C. B.). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | American Society for Biochemistry and Molecular Biology | es_ES |
dc.relation.isversionof | Publisher's version | es_ES |
dc.rights | openAccess | es_ES |
dc.subject | Function-associated antigen-1 | es_ES |
dc.subject | Nuclear factor-i | es_ES |
dc.subject | Transcription factor | es_ES |
dc.subject | Murine myeloperoxidase | es_ES |
dc.subject | Adhesion molecules | es_ES |
dc.subject | Expression | es_ES |
dc.subject | Identification | es_ES |
dc.subject | Cloning | es_ES |
dc.subject | lfa-1 | es_ES |
dc.subject | Leukemogenesis | es_ES |
dc.title | Polyomavirus enhancer-binding protein 2/core binding factor/acute myeloid leukemia factors contribute to the cell type-specific activity of the CD11a integrin gene promoter | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1074/jbc.M004323200 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1074/jbc.M004323200 | es_ES |
dc.identifier.e-issn | 1083-351X | - |
dc.contributor.funder | Comisión Interministerial de Ciencia y Tecnología, CICYT (España) | es_ES |
dc.contributor.funder | Comunidad de Madrid | es_ES |
dc.relation.csic | Sí | es_ES |
oprm.item.hasRevision | no ko 0 false | * |
dc.identifier.funder | http://dx.doi.org/10.13039/501100007273 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/100012818 | es_ES |
dc.contributor.orcid | Puig-Kröger, Amaya [0000-0003-2943-9757] | es_ES |
dc.contributor.orcid | López-Rodríguez, Cristina [0000-0002-2311-2406] | es_ES |
dc.contributor.orcid | Relloso, Miguel [0000-0002-9181-2244] | es_ES |
dc.contributor.orcid | Sánchez-Elsner, Tilman [0000-0003-1915-2410] | es_ES |
dc.contributor.orcid | Nueda, Arsenio [0000-0001-8373-500X] | es_ES |
dc.contributor.orcid | Bernabéu, Carmelo [0000-0002-1563-6162] | es_ES |
dc.contributor.orcid | Corbí, Angel L.[0000-0003-1980-5733] | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | artículo | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
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J. Biol. Chem.-2000-Puig-Kröger-28507-12.pdf | Artículo principal | 233,91 kB | Adobe PDF | Visualizar/Abrir |
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