English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/168628
COMPARTIR / IMPACTO:
Estadísticas
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Título

Missing heritability of complex diseases: Enlightenment by genetic variants from intermediate phenotypes

AutorBlanco-Gómez, Adrián ; Castillo, Sonia ; Sáez-Freire, María del Mar; Hontecillas-Prieto, Lourdes; Mao, Jian-Hua; Castellanos-Martín, Andrés ; Pérez-Losada, J.
Palabras claveComplex diseases
Heritability
Intermediate phenotype or endophenotype
Missing heritability
Fecha de publicación2016
EditorWiley-VCH
CitaciónBioEssays 38: 664-673 (2016)
ResumenDiseases of complex origin have a component of quantitative genetics that contributes to their susceptibility and phenotypic variability. However, after several studies, a major part of the genetic component of complex phenotypes has still not been found, a situation known as “missing heritability.” Although there have been many hypotheses put forward to explain the reasons for the missing heritability, its definitive causes remain unknown. Complex diseases are caused by multiple intermediate phenotypes involved in their pathogenesis and, very often, each one of these intermediate phenotypes also has a component of quantitative inheritance. Here we propose that at least part of the missing heritability can be explained by the genetic component of intermediate phenotypes that is not detectable at the level of the main complex trait. At the same time, the identification of the genetic component of intermediate phenotypes provides an opportunity to identify part of the missing heritability of complex diseases.
Versión del editorhttps://doi.org/10.1002/bies.201600084
URIhttp://hdl.handle.net/10261/168628
Identificadoresdoi: 10.1002/bies.201600084
e-issn: 1521-1878
issn: 0265-9247
Aparece en las colecciones: (IBMCC) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
missherita.pdf1,53 MBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.