English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/168529
COMPARTIR / IMPACTO:
Estadísticas
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Título

Genetic susceptibility to vascular cognitive impairment: a pathophysiological view

AutorManso-Calderón, Raquel; González-Sarmiento, Rogelio
Palabras claveMonogenic
Lipid metabolism
Inflammation
Dementia
Cerebral amyloid angiopathy
Oxidative stress
Hypoxia
Vascular cognitive impairment
Genetic variants
Blood–brain barrier
Fecha de publicación2016
EditorFuture Medicine
CitaciónFuture Neurology 11(2): 119-134 (2016)
ResumenThe heterogeneity of the vascular cognitive impairment (VCI) creates challenges for research on its genetic basis and pathophysiology. Despite well-known monogenic forms may be useful to understand some pathogenic mechanisms leading to VCI, most of VCIs are sporadic disorders resulting from the interaction between environmental, vascular and genetic factors. Genetic investigation for VCI may encompass both candidate genes that affect critical biological processes to VCI and common and rare genetic variants identified across the entire genome study technology, thereby enabling us to confirm or expose new biological mechanisms in VCI and develop new therapeutic and preventive approaches. Notwithstanding genetic susceptibility to VCI remains largely unknown owing to methodological issues. Collaborative efforts emerge as an interesting strategy to overcome these problems.
URIhttp://hdl.handle.net/10261/168529
Identificadoresdoi: 10.2217/fnl-2016-0002
e-issn: 1748-6971
issn: 1479-6708
Aparece en las colecciones: (IBMCC) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
accesoRestringido.pdf15,38 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.