English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/168436
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:

Title

Bone marrow fibrosis in myelodysplastic syndromes: a prospective evaluation including mutational analysis

AuthorsRamos, Fernando; Robledo, Cristina; Izquierdo-García, Francisco Miguel; Suárez-Vilela, Dimas; Benito, Rocío; Fuertes, Marta; Insunza, Andrés; Barragán, Eva; Rey, Mónica del; García-Ruiz de Morales, José María; Tormo, Mar; Salido, Eduardo; Zamora, Lurdes; Pedro, Carmen; Sánchez-del-Real, Javier; Díez-Campelo, María; Cañizo, María Consuelo del; Sanz, Guillermo F.; Hernández, Jesús M.
KeywordsBone marrow fibrosis
Pathogenesis
Myelodysplastic syndromes
Prognosis
Next-generation sequencing
Issue Date2016
PublisherImpact Journals
CitationOncotarget 7(21): 30492-30503 (2016)
AbstractThe biological and molecular events that underlie bone marrow fibrosis in patients with myelodysplastic syndromes are poorly understood, and its prognostic role in the era of the Revised International Prognostic Scoring System (IPSS-R) is not yet fully determined. We have evaluated the clinical and biological events that underlie bone marrow fibrotic changes, as well as its prognostic role, in a well-characterized prospective patient cohort (n=77) of primary MDS patients. The degree of marrow fibrosis was linked to parameters of erythropoietic failure, marrow cellularity, p53 protein accumulation, WT1 gene expression, and serum levels of CXCL9 and CXCL10, but not to other covariates including the IPSS-R score. The presence of bone marrow fibrosis grade 2 or higher was associated with the presence of mutations in cohesin complex genes (31.5% vs. 5.4%, p=0.006). By contrast, mutations in CALR, JAK2, PDGFRA, PDGFRB, and TP53 were very rare. Survival analysis showed that marrow fibrosis grade 2 or higher was a relevant significant predictor for of overall survival, and independent of age, performance status, and IPSS-R score in multivariate analysis.
DescriptionSpanish Group for Myelodysplastic Syndromes (GESMD).
Publisher version (URL)https://doi.org/10.18632/oncotarget.9026
URIhttp://hdl.handle.net/10261/168436
DOIhttp://dx.doi.org/10.18632/oncotarget.9026
Identifiersdoi: 10.18632/oncotarget.9026
e-issn: 1949-2553
Appears in Collections:(IBMCC) Artículos
Files in This Item:
File Description SizeFormat 
bonemarrow.pdf1,84 MBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.