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A rare but recurrent t(8;13)(q24;q14) translocation in B-cell chronic lymphocytic leukaemia causing MYC up-regulation and concomitant loss of PVT1, miR-15/16 and DLEU7

AutorMacchia, Gemma; Lonoce, Angelo; Venuto, Santina; Macrí, Ettore; Palumbo, Oracio; Carella, Massimo; Cunsolo, Crocifissa Lo; Iuzzolino, Paolo; Hernández-Sánchez, María; Hernández, Jesús M. ; Storlazzi, Clelia T.
Fecha de publicación2016
EditorJohn Wiley & Sons
CitaciónBritish Journal of Haematology 172(2): 296-299 (2016)
ResumenB-cell chronic lymphocytic leukaemia (B-CLL) is the most common haematological malignancy in Western countries. Trisomy 12 (12%), and deletions of 13q14 (50%), 11q23 (18%) and 17p13 (7%) are the most frequent chromosomal aberrations (Palamarchuk et al, 2010). 13q14 losses, associated with better prognosis, are primary changes resulting in loss of MIR15A/MIR16-1 and DLEU7 (Palamarchuk et al, 2010). Notably, the 10% of these deletions occur together with unbalanced translocations with multiple partners (Puiggros et al, 2014). Two cases with t(8;13)(q14;q24) translocations have been described, although not characterized at molecular level (Gardiner et al, 1997; Put et al, 2012). 8q24 rearrangements are generally rare in CLL and their prognostic significance is unclear.
URIhttp://hdl.handle.net/10261/168412
Identificadoresdoi: 10.1111/bjh.13482
e-issn: 1365-2141
issn: 0007-1048
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