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Título

Evaluation of the in vitro antitumor activity of natural compounds in prostate cancer

Otros títulosEvaluación de la actividad antitumoral in vitro de compuestos naturales en el cáncer de próstata
AutorNeves Craveiro, Nuno Filipe
DirectorCartea González, María Elena ; Freire-Garabal, Manuel; Núñez-Iglesias, María Jesús
Palabras claveIsothiocyanates
Prostate cancer
Isotiocianatos
Cáncer de próstata
Fecha de publicación7-jul-2014
EditorUniversidad de Santiago de Compostela
CSIC - Misión Biológica de Galicia (MBG)
CitaciónEvaluation of the in vitro antitumor activity of natural compounds in prostate cancer (2014)
ResumenIsothiocyanates (ITCs), natural compounds found in several vegetables, have demonstrated some chemopreventive and anti-cancer activities both under in vitro and in vivo conditions. In this study, we assayed the effects of 2 ITCs found in turnip tops grown in Galicia, PTC and 4PI, that were not previously tested on cancer models, on the survival and proliferation of cultured PC-3 and DU-145 prostate cancer (PCA) cells in the presence or in absence of anti-cancer drug docetaxel. Our results show that PTC inhibited in a significant manner the viability of PCA cells at different interval (24, 48 and 72 h) in a dose-dependent manner. Furthermore, this compound potentiated the effects of docetaxel on both parameters in a significant manner. On the contrary, 4PI showed no effect. These results let us hypothesize that PTC may find use in the treatment of human prostate cancers, both as chemopreventive and anti-cancer drugs, and can result in nutritional recommendations for cancer patients.
Descripción8 páginas.- Trabajo Fin de Grado
URIhttp://hdl.handle.net/10261/168197
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