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dc.contributor.authorNavarro-Martín, Laia-
dc.contributor.authorGalay-Burgos, Malyka-
dc.contributor.authorSweeney, Glen E.-
dc.contributor.authorPiferrer, Francesc-
dc.identifier.citationMolecular and Cellular Endocrinology 299(2): 240-251 (2009)en_US
dc.description12 pages, 8 figures, 2 tables.-- PMID: 19071190 [PubMed].-- Available online Nov 21, 2008.-- Supporting information (Suppl. figures S1-S3) available at: https://doi.org/10.1016/j.mce.2008.11.013en_US
dc.description.abstractSox genes participate in several developmental processes, including sex determination and differentiation. In this study, the genomic structure of sox17 was characterized in the sea bass (sb). Two transcripts, one producing a normal protein (sb Sox17) and another producing a truncated protein (sb t-Sox17) were detected. A third, novel transcript, originated by intron retention (sb i-sox17) was also observed. Sb sox17 was widely distributed, whereas sb i-sox17 was predominantly found in skin and brain. In gonads, sb sox17 expression first increased at 150 days of age, coinciding with the onset of sex differentiation. At 250 days and onwards, sb sox17 expression was significantly higher in females, and mRNA levels correlated with those of gonadal aromatase. Thus, this study provides the first evidence for the presence of alternative splicing by intron retention in a Sox17 gene, and for sex-related differences in expression, implicating sox17 in ovarian development and function in fish.en_US
dc.description.sponsorshipL.N. was supported by the Spanish Ministry of Education and Science (MEC) predoctoral fellowship BES-2003-0006. Research carried out with the financial support of the Commission of the European Union, Quality of Life and Management of Living Resources specific RTD programme (Project Q5RS-2000-31365, "Probass"), to G.S and F.P, and of the MEC project "Sexratio" (AGL2002-02636) to F.P.en_US
dc.format.extent918459 bytes-
dc.subjectGonadal differentiationen_US
dc.subjectAlternative splicingen_US
dc.subjectSea bassen_US
dc.titleDifferent sox17 transcripts during sex differentiation in sea bass, Dicentrarchus labraxen_US
dc.description.peerreviewedPeer revieweden_US
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