English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/16818
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:

DC FieldValueLanguage
dc.contributor.authorNavarro-Martín, Laia-
dc.contributor.authorGalay-Burgos, Malyka-
dc.contributor.authorSweeney, Glen E.-
dc.contributor.authorPiferrer, Francesc-
dc.date.accessioned2009-09-10T09:13:46Z-
dc.date.available2009-09-10T09:13:46Z-
dc.date.issued2009-02-27-
dc.identifier.citationMolecular and Cellular Endocrinology 299(2): 240-251 (2009)en_US
dc.identifier.issn0303-7207-
dc.identifier.urihttp://hdl.handle.net/10261/16818-
dc.description12 pages, 8 figures, 2 tables.-- PMID: 19071190 [PubMed].-- Available online Nov 21, 2008.-- Supporting information (Suppl. figures S1-S3) available at: https://doi.org/10.1016/j.mce.2008.11.013en_US
dc.description.abstractSox genes participate in several developmental processes, including sex determination and differentiation. In this study, the genomic structure of sox17 was characterized in the sea bass (sb). Two transcripts, one producing a normal protein (sb Sox17) and another producing a truncated protein (sb t-Sox17) were detected. A third, novel transcript, originated by intron retention (sb i-sox17) was also observed. Sb sox17 was widely distributed, whereas sb i-sox17 was predominantly found in skin and brain. In gonads, sb sox17 expression first increased at 150 days of age, coinciding with the onset of sex differentiation. At 250 days and onwards, sb sox17 expression was significantly higher in females, and mRNA levels correlated with those of gonadal aromatase. Thus, this study provides the first evidence for the presence of alternative splicing by intron retention in a Sox17 gene, and for sex-related differences in expression, implicating sox17 in ovarian development and function in fish.en_US
dc.description.sponsorshipL.N. was supported by the Spanish Ministry of Education and Science (MEC) predoctoral fellowship BES-2003-0006. Research carried out with the financial support of the Commission of the European Union, Quality of Life and Management of Living Resources specific RTD programme (Project Q5RS-2000-31365, "Probass"), to G.S and F.P, and of the MEC project "Sexratio" (AGL2002-02636) to F.P.en_US
dc.format.extent918459 bytes-
dc.format.mimetypeapplication/pdf-
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsclosedAccessen_US
dc.subjectSox17en_US
dc.subjectDevelopmenten_US
dc.subjectGonadal differentiationen_US
dc.subjectAlternative splicingen_US
dc.subjectSea bassen_US
dc.titleDifferent sox17 transcripts during sex differentiation in sea bass, Dicentrarchus labraxen_US
dc.typeartículoen_US
dc.identifier.doihttp://dx.doi.org/10.1016/j.mce.2008.11.013-
dc.description.peerreviewedPeer revieweden_US
dc.relation.publisherversionhttps://doi.org/10.1016/j.mce.2008.11.013en_US
Appears in Collections:(ICM) Artículos
Files in This Item:
There are no files associated with this item.
Show simple item record
 


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.