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Different sox17 transcripts during sex differentiation in sea bass, Dicentrarchus labrax

AutorNavarro-Martín, Laia ; Galay-Burgos, Malyka; Sweeney, Glen E.; Piferrer, Francesc
Palabras claveSox17
Gonadal differentiation
Alternative splicing
Sea bass
Fecha de publicación27-feb-2009
CitaciónMolecular and Cellular Endocrinology 299(2): 240-251 (2009)
ResumenSox genes participate in several developmental processes, including sex determination and differentiation. In this study, the genomic structure of sox17 was characterized in the sea bass (sb). Two transcripts, one producing a normal protein (sb Sox17) and another producing a truncated protein (sb t-Sox17) were detected. A third, novel transcript, originated by intron retention (sb i-sox17) was also observed. Sb sox17 was widely distributed, whereas sb i-sox17 was predominantly found in skin and brain. In gonads, sb sox17 expression first increased at 150 days of age, coinciding with the onset of sex differentiation. At 250 days and onwards, sb sox17 expression was significantly higher in females, and mRNA levels correlated with those of gonadal aromatase. Thus, this study provides the first evidence for the presence of alternative splicing by intron retention in a Sox17 gene, and for sex-related differences in expression, implicating sox17 in ovarian development and function in fish.
Descripción12 pages, 8 figures, 2 tables.-- PMID: 19071190 [PubMed].-- Available online Nov 21, 2008.-- Supporting information (Suppl. figures S1-S3) available at: http://dx.doi.org/10.1016/j.mce.2008.11.013
Versión del editorhttp://dx.doi.org/10.1016/j.mce.2008.11.013
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