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http://hdl.handle.net/10261/167997
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Gasull-Camós, Júlia | es_ES |
dc.contributor.author | Martínez-Torres, Sara | es_ES |
dc.contributor.author | Tarrés-Gatius, Mireia | es_ES |
dc.contributor.author | Ozaita, Andrés | es_ES |
dc.contributor.author | Artigas, Francesc | es_ES |
dc.contributor.author | Castañé, Anna | es_ES |
dc.date.accessioned | 2018-07-27T07:01:39Z | - |
dc.date.available | 2018-07-27T07:01:39Z | - |
dc.date.issued | 2018-09-01 | - |
dc.identifier.citation | Neuropharmacology 139: 41-51 (2018) | es_ES |
dc.identifier.issn | 0028-3908 | - |
dc.identifier.uri | http://hdl.handle.net/10261/167997 | - |
dc.description.abstract | Novel fast-acting antidepressant strategies, such as ketamine and deep brain stimulation, enhance glutamatergic neurotransmission in medial prefrontal cortex (mPFC) regions via AMPA receptor (AMPA-R) activation. We recently reported that the regionally-selective blockade of the glial glutamate transporter-1 (GLT-1) by dihydrokainic acid (DHK) microinfusion in rat infralimbic cortex (IL), the most ventral part of the mPFC, evoked immediate (10 min) antidepressant-like responses, which involved AMPA-R activation and were associated to increased serotonin (5-hydroxytryptamine, 5-HT) release. Given the reciprocal connectivity between the mPFC and the serotonergic dorsal raphe nucleus (DR), here we examined the serotoninergic mechanisms involved in the reported antidepressant-like responses of DHK microinfusion. First, we show that antidepressant-like responses evoked by IL application of DHK and citalopram are mediated by local 5-HT1A receptors (5-HT1A-R), since they are cancelled by previous IL WAY100635 microinfusion. Second, IL DHK microinfusion increases excitatory inputs onto DR, as shown by an increased glutamate and 5-HT release in DR and by a selective increase of c-Fos expression in DR 5-HT neurons, not occurring in putative GABAergic neurons. This view is also supported by an increased 5-HT release in ventral hippocampus following IL DHK microinfusion. Interestingly, antidepressant-like responses evoked by IL DHK lasted for 2 h and could be prolonged for up to 24 h by attenuating self-inhibitory effects via 5-HT1A autoreceptors. In contrast, the antidepressant-like effects of S-AMPA microinfusion in IL were short-lasting. Together, our results further support a prominent role of the IL–DR pathway and of ascending 5-HT pathways in mediating antidepressant-like responses evoked by glutamatergic mechanisms. | es_ES |
dc.description.sponsorship | This work was supported by the Spanish Ministry of Economy and Competitiveness (SAF2015-68346 and BES2013-063241 to J.G-C; BFU2015-68568-P to A.O.) co-financed by European Regional Development Fund; Generalitat de Catalunya (CERCA Programme; 2014-SGR798, 2016FI-B00285 to M.T-G, 2016 FI-B00531 to S.M-T and ICREA Acadèmia to A.O.); Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2015-68346-P | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2015-68568-P | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BES2013-063241 | es_ES |
dc.relation.isversionof | Postprint | es_ES |
dc.rights | openAccess | en_EN |
dc.subject | Antidepressant effects | es_ES |
dc.subject | Dihydrokainic acid | es_ES |
dc.subject | Dorsal raphe | es_ES |
dc.subject | GLT-1 | es_ES |
dc.subject | Infralimbic cortex | es_ES |
dc.subject | Serotonin | es_ES |
dc.title | Serotonergic mechanisms involved in antidepressant-like responses evoked by GLT-1 blockade in rat infralimbic cortex | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1016/j.neuropharm.2018.06.029 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | https://doi.org/10.1016/j.neuropharm.2018.06.029 | es_ES |
dc.identifier.e-issn | 1873-7064 | - |
dc.embargo.terms | 2019-09-01 | es_ES |
dc.rights.license | http://creativecommons.org/licenses/by-nc-nd/4.0/ | - |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | es_ES |
dc.contributor.funder | European Commission | es_ES |
dc.contributor.funder | Generalitat de Catalunya | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.contributor.funder | Centro de Investigación Biomédica en Red Salud Mental (España) | es_ES |
dc.relation.csic | Sí | es_ES |
oprm.item.hasRevision | no ko 0 false | * |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004587 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100002809 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100006751 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
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