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EMT in cancer

AutorBrabletz, Thomas; Kalluri, Raghu; Nieto, M. Ángela ; Weinberg, Robert A.
Fecha de publicación12-ene-2018
EditorSpringer Nature
CitaciónNature Reviews Cancer 18: 128-134 (2018)
ResumenSimilar to embryonic development, changes in cell phenotypes defined as an epithelial to mesenchymal transition (EMT) have been shown to play a role in the tumorigenic process. Although the first description of EMT in cancer was in cell cultures, evidence for its role in vivo is now widely reported but also actively debated. Moreover, current research has exemplified just how complex this phenomenon is in cancer, leaving many exciting, open questions for researchers to answer in the future. With these points in mind, we asked four scientists for their opinions on the role of EMT in cancer and the challenges faced by scientists working in this fast-moving field.
Versión del editorhttp://dx.doi.org/10.1038/nrc.2017.118
URIhttp://hdl.handle.net/10261/167805
DOI10.1038/nrc.2017.118
ISSN1474-175X
E-ISSN1474-1768
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