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Title

Upholding a role for EMT in breast cancer metastasis

AuthorsYe, Xin; Brabletz, Thomas; Kang, Yibin; Longmore, Gregory D.; Nieto, M. Ángela CSIC ORCID ; Stanger, Ben Z.; Yang, Jing; Weinberg, Robert A.
Issue Date6-Jul-2017
PublisherSpringer Nature
CitationNature 547: E1-E6 (2017)
AbstractThe cell-biological program termed the epithelial-to-mesenchymal transition (EMT) has been invoked as a critical component of the metastatic process. Contrastingly, Fischer et al.1 recently reported that in two genetically engineered mouse models of mammary tumour development, carcinoma cells could metastasize without activating EMT programs. However, as detailed below, we find their evidence that EMT programs were not expressed in these primary tumours to be insufficient. Therefore, the contribution of EMT to carcinoma metastasis could not be ruled out in their analysis. There is a Reply to this Comment by Fischer, K. R. et al. Nature 547, 10.1038/nature22817 (2017).
Publisher version (URL)http://dx.doi.org/10.1038/nature22816
URIhttp://hdl.handle.net/10261/167803
DOI10.1038/nature22816
ISSN0028-0836
E-ISSN1476-4687
Appears in Collections:(IN) Artículos




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