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Título: | Dendritic cell (DC)-specific intercellular adhesion molecule 3 (ICAM-3)-grabbing nonintegrin (DC-SIGN, CD209), a C-type surface lectin in human DCs, is a receptor for Leishmania amastigotes |
Autor: | Colmenares, María ; Puig-Kröger, Amaya CSIC ORCID; Muñiz, Óscar; Corbí, Angel L. ; Rivas, Luis CSIC ORCID | Palabras clave: | Cutaneous leishmaniasis T-cells Major amastigotes Langerhans cells Immune-responses In-vitro Antigens Panamensis Activation Mexicana |
Fecha de publicación: | 27-sep-2002 | Editor: | American Society for Biochemistry and Molecular Biology | Citación: | J Biol Chem 277(39):36766-9 (2002) | Resumen: | Dendritic cells (DCs) play a critical role in the initiation of the immunological response against Leishmania parasites. However, the receptors involved in amastigote-dendritic cell interaction are unknown, especially in absence of opsonizing antibodies. We have studied the interaction of Leishmania pifanoi axenic amastigotes with the C-type lectin DC-specific intercellular adhesion molecule (ICAM)-3-grabbing nonintegrin (DC-SIGN, CD209), a receptor for ICAM-2, ICAM-3, human immunodeficiency virus gp120, and Ebola virus. L. pifanoi amastigotes interact with immature human dendritic cells and CD209-transfected K562 cells in a time- and dose-dependent manner. Leishmania amastigote binding to human dendritic cells and DC-SIGN-transfected cells is inhibited by a function-blocking DC-SIGN-specific monoclonal antibody. More importantly, this monoclonal antibody dramatically reduces internalization of Leishmania amastigotes by immature human DCs. These results constitute the first description of a nonviral pathogen ligand for DC-SIGN and provide evidence for a relevant role of DC-SIGN in Leishmania amastigote uptake by dendritic cells. Our finding has important implications for Leishmania host-cell interaction and the immunoregulation of cutaneous leishmaniasis. | Descripción: | 5 p.-4 fig-1 tab. | Versión del editor: | http://dx.doi.org/10.1074/jbc.M205270200 | URI: | http://hdl.handle.net/10261/167666 | DOI: | 10.1074/jbc.M205270200 | ISSN: | 0021-9258 | E-ISSN: | 1083-351X |
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J. Biol. Chem.-2002-Colmenares-36766-9.pdf | Artículo principal | 173,32 kB | Adobe PDF | Visualizar/Abrir |
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