English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/167266
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:

Title

Drug repositioning for novel antitrichomonas from known antiprotozoan drugs using hierarchical screening

AuthorsMeneses-Marcel, Alfredo; Marrero-Ponce, Yovani; Ibáñez-Escribano, Alexandra; Gómez-Barrio, Alicia; Escario, José Antonio; Barigye, S. J.; Terán, E.; García-Jacas, C. R.; Machado-Tugores, Yanesty; Nogal-Ruiz, Juan José; Arán-Redó, Vicente J.
KeywordsToMoCoMD-CARDD
QuBiLS-MAS
QSAR
Antitrichomonas
Trichomonas vaginalis
Issue Date2018
PublisherFuture Science
CitationFuture Medicinal Chemistry 10: 863-878 (2018)
AbstractAim: Metronidazole is the most widely used drug in trichomoniasis therapy. However, the emergence of metronidazole-resistant Trichomonas vaginalis isolates calls for the search for new drugs to counter the pathogenicity of these parasites. Results: Classification models for predicting the antitrichomonas activity of molecules were built. These models were employed to screen antiprotozoal drugs, from which 20 were classified as active. The in vitro experiments showed moderate to high activity for 19 of the molecules at 10 μg/ml, while 3 compounds yielded higher activity than the reference at 1 μg/ml. The 11 most active chemicals were evaluated in vivo using Naval Medical Research Institute (NMRI) mice. Conclusion: Benznidazole showed similar results as metronidazole, and can thus be considered as a potential candidate in antitrichomonas therapy.
Publisher version (URL)http://dx.doi.org/10.4155/fmc-2016-0211
URIhttp://hdl.handle.net/10261/167266
DOIhttp://dx.doi.org/10.4155/fmc-2016-0211
Identifiersdoi: 10.4155/fmc-2016-0211
issn: 1756-8919
e-issn: 1756-8927
Appears in Collections:(IQM) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.