English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/16678
Compartir / Impacto:
Estadísticas
Add this article to your Mendeley library MendeleyBASE
Citado 0 veces en Web of Knowledge®  |  Ver citas en Google académico
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Título

Analysis by liquid chromatography-electrospray ionization tandem mass spectrometry and acute toxicity evaluation for beta-blockers and lipid-regulating agents in wastewater samples

AutorHernando, María Dolores; Petrovic, Mira; Fernández Alba, Amadeo R.; Barceló, Damià
Palabras claveWater analysis
Lipid-regulating agents
Environmental analysis
Toxicity
Daphnia magna
β-Blockers
Fecha de publicación24-jul-2004
EditorElsevier
CitaciónJournal of Chromatography A 1046(1-2): 133-140 (2004)
ResumenThis paper describes a multiresidue method for the extraction and determination of two therapeutic groups of pharmaceuticals, lipid-regulating agents (clofibric acid, bezafibrate, gemfibrocil, fenofibrate) and β-blockers (atenolol, sotalol, metoprolol, betaxolol) in waters by solid-phase extraction followed by liquid chromatography-electrospray ionization tandem mass spectrometry (LC–ESI-MS–MS). Recoveries obtained from spiked HPLC water, as well as, from spiked real samples (sewage treatment plants influent and effluents, river and tap water) were all above 60%, with the exception of betaxolol with a 52% recovery. The quantitative MS analysis was performed using a multiple reaction monitoring. The LC–MS–MS method gave detection limits ranging from 0.017 to 1.25 μg/l in spiked effluent. Precision of the method, calculated as relative standard deviation, ranged from 3.7 to 18.5%. Individual and combined effects on Daphnia magna were evaluated for both therapeutic groups. Individual effects in culture medium showed these compounds as not harmful and not toxic, an exception is fenofibrate that was found to be harmful, but at high, in the environment unrealistic concentrations (EC50 of 50 mg/l). Combined effect in wastewater showed synergistic toxic effects at low concentration level (2 μg/l).
Descripción8 pages, 2 figures, 3 tables.-- PMID: 15387181 [PubMed].-- Printed version published Aug 13, 2004.-- Presented at the 3rd Meeting of the Spanish Association of Chromatography and Related Techniques and the European Workshop: 3rd Waste Water Cluster, Aguadulce (Almeria), Spain, Nov 19–21, 2003.
Versión del editorhttp://dx.doi.org/10.1016/j.chroma.2004.06.102
URIhttp://hdl.handle.net/10261/16678
DOI10.1016/j.chroma.2004.06.102
ISSN0021-9673 (Print)
1873-3778 (Online)
Aparece en las colecciones: (IDAEA) Artículos
Ficheros en este ítem:
No hay ficheros asociados a este ítem.
Mostrar el registro completo
 



NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.