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Título

Complexation of sesquiterpene lactones with cyclodextrins: synthesis and effects on their activities on parasitic weeds

AutorCala, Antonio; Molinillo, José M. G.; Fernández-Aparicio, Mónica ; Ayuso, Jesús; Álvarez, José A.; Rubiales, Diego ; Macías, Francisco A.
Fecha de publicación2017
EditorRoyal Society of Chemistry (Great Britain)
CitaciónOrganic and Biomolecular Chemistry 15: 6500-6510 (2017)
ResumenAllelochemicals are safer, more selective and more active alternatives than synthetic agrochemicals for weed control. However, the low solubility of these compounds in aqueous media limits their use as agrochemicals. Herein, we propose the application of α-, β- and γ-cyclodextrins to improve the physicochemical properties and biological activities of three sesquiterpene lactones: dehydrocostuslactone, costunolide and (−)-α-santonin. Complexation was achieved by kneading and coprecipitation methods. Aqueous solubility was increased in the range 100–4600% and the solubility–phase diagrams suggested that complex formation had been successful. The results of the PM3 semiempirical calculations were consistent with the experimental results. The activities on etiolated wheat coleoptiles, Standard Target Species and parasitic weeds were improved. Cyclodextrins preserved or enhanced the activity of the three sesquiterpene lactones. Free cyclodextrins did not show significant activity and therefore the enhancement in activity was due to complexation. These results are promising for applications in agrochemical design.
Versión del editorhttp://dx.doi.org/10.1039/c7ob01394a
URIhttp://hdl.handle.net/10261/166703
DOI10.1039/c7ob01394a
ISSN1477-0520
E-ISSN1477-0539
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