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Título: | Hox2 Genes Are Required for Tonotopic Map Precision and Sound Discrimination in the Mouse Auditory Brainstem |
Autor: | Karmakar, Kajari; Di Meglio, Thomas; Rijli, Filippo M. | Fecha de publicación: | 3-ene-2017 | Editor: | Cell Press | Citación: | Cell Reports 18: 185- 197 (2017) | Resumen: | Tonotopy is a hallmark of auditory pathways and provides the basis for sound discrimination. Little is known about the involvement of transcription factors in brainstem cochlear neurons orchestrating the tonotopic precision of pre-synaptic input. We found that in the absence of Hoxa2 and Hoxb2 function in Atoh1-derived glutamatergic bushy cells of the anterior ventral cochlear nucleus, broad input topography and sound transmission were largely preserved. However, fine-scale synaptic refinement and sharpening of isofrequency bands of cochlear neuron activation upon pure tone stimulation were impaired in Hox2 mutants, resulting in defective sound-frequency discrimination in behavioral tests. These results establish a role for Hox factors in tonotopic refinement of connectivity and in ensuring the precision of sound transmission in the mammalian auditory circuit | URI: | http://hdl.handle.net/10261/166130 | DOI: | 10.1016/j.celrep.2016.12.021 | Identificadores: | doi: 10.1016/j.celrep.2016.12.021 issn: 2211-1247 |
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DiMeglioT_Hox2GenesAreRequired.pdf | 4,87 MB | Adobe PDF | Visualizar/Abrir |
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