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Title

Hox2 Genes Are Required for Tonotopic Map Precision and Sound Discrimination in the Mouse Auditory Brainstem

AuthorsKarmakar, Kajari; Di Meglio, Thomas; Rijli, Filippo M.
Issue Date3-Jan-2017
PublisherCell Press
CitationCell Reports 18: 185- 197 (2017)
AbstractTonotopy is a hallmark of auditory pathways and provides the basis for sound discrimination. Little is known about the involvement of transcription factors in brainstem cochlear neurons orchestrating the tonotopic precision of pre-synaptic input. We found that in the absence of Hoxa2 and Hoxb2 function in Atoh1-derived glutamatergic bushy cells of the anterior ventral cochlear nucleus, broad input topography and sound transmission were largely preserved. However, fine-scale synaptic refinement and sharpening of isofrequency bands of cochlear neuron activation upon pure tone stimulation were impaired in Hox2 mutants, resulting in defective sound-frequency discrimination in behavioral tests. These results establish a role for Hox factors in tonotopic refinement of connectivity and in ensuring the precision of sound transmission in the mammalian auditory circuit
URIhttp://hdl.handle.net/10261/166130
Identifiersdoi: 10.1016/j.celrep.2016.12.021
issn: 2211-1247
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