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Overcoming aminoglycoside enzymatic resistance: Design of novel antibiotics and inhibitors

AuthorsZárate, Sandra G.; De La Cruz Claure, M. L.; Benito-Arenas, Raúl; Revuelta, Julia ; Santana, Andrés G. ; Bastida, Agatha
KeywordsAntibiotic resistance
combination therapy
Decoy acceptors
Bi-substrate inhibitors
Issue Date2018
PublisherMolecular Diversity Preservation International
CitationMolecules 23 (2018)
AbstractResistance to aminoglycoside antibiotics has had a profound impact on clinical practice. Despite their powerful bactericidal activity, aminoglycosides were one of the first groups of antibiotics to meet the challenge of resistance. The most prevalent source of clinically relevant resistance against these therapeutics is conferred by the enzymatic modification of the antibiotic. Therefore, a deeper knowledge of the aminoglycoside-modifying enzymes and their interactions with the antibiotics and solvent is of paramount importance in order to facilitate the design of more effective and potent inhibitors and/or novel semisynthetic aminoglycosides that are not susceptible to modifying enzymes.
Publisher version (URL)http://dx.doi.org/10.3390/molecules23020284
Identifiersdoi: 10.3390/molecules23020284
issn: 1420-3049
issn: 1420-3049
Appears in Collections:(IQOG) Artículos
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