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Reversal of the predetermined pattern of MTOC distribution during the asymmetric cell division of budding yeast accelerates cellular aging

AutorManzano-Lopez, Javier; Monje-Casas, Fernando
Fecha de publicación2017
CitaciónWorkshop Current Trends in Biomedicine (2017)
ResumenDespite cellular division during mitosis usually involving an equal distribution of the genome and the cellular components between the mother and the daughter cell, there are many examples of asymmetric cell divisions. A stereotypical example of cells displaying asymmetric cellular division are stem cells. The asymmetry during the division of stem cells allows them to self-renew while also producing another cell that, based on the inheritance of specific cell-fate determinants, enters a particular differentiation program. Defects during the asymmetric division of stem cells can lead to tissue degeneration or aging if stem cell number is reduced or, alternatively, to tumorigenesis or tissue hyperplasia if their number is increased. Therefore, the analysis of the regulation of asymmetric cell divisions is of pivotal importance. An extremely interesting phenomenon associated to some asymmetric cell divisions is the differential inheritance of the microtubule organizing centers (MTOCs) from which the microtubules that form the mitotic spindle emanate. This phenomenon has been described during the division of budding yeast, neuroblasts and male germline stem cells from Drosophila, radial glia cell progenitors from mice, or human neuroblastoma cell lines. However, little is known about how pre-established MTOC inheritance patterns are generated and, more importantly, about their biological function. Using budding yeast as a model, and taking advantage of the powerful molecular tools developed for this organism, we have generated a system to evaluate the functional consequences of the reversal of a pre-established asymmetric MTOC inheritance pattern. Our results show that constitutive reversal of the asymmetry in the distribution of the SPBs in budding yeast does not affect cell viability or cell cycle progression, but determines a reduction in the life span of the cells. Unveiling the functional significance of the establishment of differential MTOC distribution patterns could help us in the future to better understand pathologies that may arise as a result of problems during the establishment of this asymmetry.
DescripciónResumen del trabajo presentado al Workshop Current Trends in Biomedicine: "Chromosomal instability: from molecular mechanisms to disease", celebrado en Baeza (España) del 13 al 15 de noviembre de 2017.
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