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Emerging roles of chromatin in the maintenance of genome organization and function in plants

AutorVergara, Zaida ; Gutiérrez Armenta, Crisanto
Fecha de publicación2017
EditorBioMed Central
CitaciónGENOME BIOLOGY 18 (2017)
ResumenChromatin is not a uniform macromolecular entity; it contains different domains characterized by complex signatures of DNA and histone modifications. Such domains are organized both at a linear scale along the genome and spatially within the nucleus. We discuss recent discoveries regarding mechanisms that establish boundaries between chromatin states and nuclear territories. Chromatin organization is crucial for genome replication, transcriptional silencing, and DNA repair and recombination. The replication machinery is relevant for the maintenance of chromatin states, influencing DNA replication origin specification and accessibility. Current studies reinforce the idea of intimate crosstalk between chromatin features and processes involving DNA transactions.
URIhttp://hdl.handle.net/10261/165858
Identificadoresdoi: 10.1186/s13059-017-1236-9
issn: 1474-760X
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