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Sirt1 activators induced neuroprotection of photoreceptors in rd10 mice

AuthorsDíaz-Corrales, Francisco J. ; Morales, Juan C.; Valdés-Sánchez, María Lourdes; Lucas, Ricardo ; García-Delgado, Ana B.; Rodriguez-Martinez, Daniel; Peñalver, Pablo ; Díez-Lloret, Andrea ; Bhatia, Vaibhav; Cerda, Berta de la ; Rodriguez-Bocanegra, Eduardo; Bhattacharya, Shom Shanker
Issue Date2016
CitationARVO 2016
AbstractIt has been report ed that Sirt1 nuclear expression decreases in the outer nuclear layer (ONL) of retinal degeneration 10 (rd10 ) mice at postnatal day 15 (P15), and this abnormal pattern is correlated with the beginning of photoreceptor degeneration. Sirt1 is a class III histone deacetylase, and over-­expression of these p roteins have shown neuroprotective effect in several experimental models of neurodegenerative diseases. However, it is still unknown whether Sirt1 modulation could induce neuroprotection of ph otoreceptors. We tested the hypothesis that subretinal injection of new Sirt1 activators would slow degeneration of photoreceptors using an experimental mouse model of autosomal recessive retinitis pigmentosa (RP).
DescriptionPóster presentado al Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO), celebrado en Seattle, Washington (US) del 1 al 5 de mayo de 2016.
Appears in Collections:(IPBLN) Comunicaciones congresos
(CABIMER) Comunicaciones congresos
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