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Título: | Distinct regenerative potential of trunk and appendages of Drosophila mediated by JNK signalling. |
Autor: | Martín, Raquel; Pinal, Noelia; Morata, Ginés CSIC ORCID | Palabras clave: | Appendages JNK Trunk Regeneration Wing disc Drosophila |
Fecha de publicación: | 11-sep-2017 | Editor: | Company of Biologists | Citación: | Development (2017) | Resumen: | The Drosophila body comprises a central part, the trunk, and outgrowths of the trunk, the appendages. Much is known about appendage regeneration, but little about the trunk. As the wing imaginal disc contains a trunk component, the notum, and a wing appendage, we have investigated the response to ablation of these two components.We find that, in contrast with the strong regenerative response of the wing, the notum does not regenerate. Nevertheless, the elimination of the wing primordium elicits a proliferative response of notum cells, but they do not regenerate wing; they form a notum duplicate. Conversely, the wing cells cannot regenerate an ablated notum; they verproliferate and generate a hinge overgrowth. These results suggest that trunk and appendages cannot be reprogrammed to generate each other. Our experiments demonstrate that the proliferative response is mediated by JNK signalling from dying cells, but JNK functions differently in the trunk and the appendages, which may explain their distinct regenerative potential | URI: | http://hdl.handle.net/10261/165790 | DOI: | 10.1242/dev.155507 | Identificadores: | doi: 10.1242/dev.155507 issn: 0959-1991 |
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MorataG_DistinctRegenerativePotential.pdf | 5,12 MB | Adobe PDF | Visualizar/Abrir |
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