Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/165593
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Caballano-Infantes, Estefanía | - |
dc.contributor.author | Terrón-Bautista, José | - |
dc.contributor.author | Beltrán-Povea, Amparo | - |
dc.contributor.author | Cahuana, Gladys M. | - |
dc.contributor.author | Soria Escoms, Bernat | - |
dc.contributor.author | Nabil, Hajji | - |
dc.contributor.author | Bedoya Bergua, Francisco Javier | - |
dc.contributor.author | Tejedo Huamán, Juan Rigoberto | - |
dc.date.accessioned | 2018-06-04T10:41:23Z | - |
dc.date.available | 2018-06-04T10:41:23Z | - |
dc.date.issued | 2017 | - |
dc.identifier | doi: 10.4252/wjsc.v9.i2.26 | - |
dc.identifier | e-issn: 1948-0210 | - |
dc.identifier.citation | World Journal of Stem Cells 9(2): 26-36 (2017) | - |
dc.identifier.uri | http://hdl.handle.net/10261/165593 | - |
dc.description.abstract | Mitochondrial dysfunction and endoplasmic reticulum stress (ERS) are global processes that are interrelated and regulated by several stress factors. Nitric oxide (NO) is a multifunctional biomolecule with many varieties of physiological and pathological functions, such as the regulation of cytochrome c inhibition and activation of the immune response, ERS and DNA damage; these actions are dose-dependent. It has been reported that in embryonic stem cells, NO has a dual role, controlling differentiation, survival and pluripotency, but the molecular mechanisms by which it modulates these functions are not yet known. Low levels of NO maintain pluripotency and induce mitochondrial biogenesis. It is well established that NO disrupts the mitochondrial respiratory chain and causes changes in mitochondrial Ca flux that induce ERS. Thus, at high concentrations, NO becomes a potential differentiation agent due to the relationship between ERS and the unfolded protein response in many differentiated cell lines. Nevertheless, many studies have demonstrated the need for physiological levels of NO for a proper ERS response. In this review, we stress the importance of the relationships between NO levels, ERS and mitochondrial dysfunction that control stem cell fate as a new approach to possible cell therapy strategies. | - |
dc.description.sponsorship | Supported by Ministerio de Ciencia e Innovación - Bernat Soria - Innpacto Proyect, No. IPT-2011-1615-900000; Instituto de Salud Carlos III, Gobierno de España - Bernat Soria, No. TERCEL RD06/0010/0025; Consejeria de Salud Junta de Andalucia Francisco Javier Bedoya Bergua, No. PI-0105-2010; Consejeria de Economia Innovación Ciencia y Empleo - Junta de Andalucia Francisco Javier Bedoya, No. CTS-7127/2011. | - |
dc.publisher | Baishideng Publishing Group | - |
dc.relation.isversionof | Publisher's version | - |
dc.rights | openAccess | - |
dc.subject | Nitric oxide | - |
dc.subject | Endoplasmic reticulum stress | - |
dc.subject | Mitochondrial function | - |
dc.subject | Pluripotency | - |
dc.subject | Cell differentiation | - |
dc.subject | Mitochondrial biogenesis | - |
dc.title | Regulation of mitochondrial function and endoplasmic reticulum stress by nitric oxide in pluripotent stem cells | - |
dc.type | artículo | - |
dc.identifier.doi | 10.4252/wjsc.v9.i2.26 | - |
dc.relation.publisherversion | https://doi.org/10.4252/wjsc.v9.i2.26 | - |
dc.date.updated | 2018-06-04T10:41:23Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.rights.license | http://creativecommons.org/licenses/by-nc/4.0/ | - |
dc.contributor.funder | Instituto de Salud Carlos III | - |
dc.contributor.funder | Junta de Andalucía | - |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004587 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004837 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100011011 | es_ES |
dc.identifier.pmid | 28289506 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.openairetype | artículo | - |
Aparece en las colecciones: | (CABIMER) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
regulacell.pdf | 952,74 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
8
checked on 18-abr-2024
SCOPUSTM
Citations
15
checked on 21-abr-2024
WEB OF SCIENCETM
Citations
15
checked on 27-feb-2024
Page view(s)
310
checked on 24-abr-2024
Download(s)
270
checked on 24-abr-2024