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Chiral magnetic-nanobiofluids for rapid electrochemical screening of enantiomers at a magneto nanocomposite graphene-paste electrode

AutorMuñoz Martín, José M. ; González Campo, Arántzazu ; Riba Moliner, Marta ; Baeza, Mireia; Mas Torrent, Marta
Palabras claveβ-Cyclodextrin
Biosensing
Enantiorecognition
Supramolecular chemistry
Tryptophan
Fecha de publicación15-may-2018
EditorElsevier
CitaciónBiosensors and Bioelectronics 105: 95-102 (2018)
ResumenThe development of highly sensitive and selective enantiomeric platforms towards the rapid screening of active pharmaceutical ingredients (APIs) is nowadays a crucial challenge in several fields related to pharmacology, biomedicine, biotechnology and (bio)sensors. Herein, it is presented a novel, facile and generic methodology focused on exploiting the synergistically and electrocatalytic properties of chiral magnetic-nanobiofluids (mNBFs) with electrochemical enantiobiosensing at a magneto nanocomposite graphene paste electrode (mNC–GPE). The feasibility of this approach has been validated by chirally recognizing tryptophan (TRP) enantiomers as a proof-of-concept. For this aim, a specific chiral mNBF based on an aqueous dispersion of cobalt ferrite loaded with gold nanoparticles carrying a thiolated β-cyclodextrin (β–CD-SH/Au/CoFe2O4–NPs) has been synthesized and used towards the supramolecular discrimination of TRP enantiomers at an advanced graphene-paste transducer via cyclic voltammetry. This strategy, which is the first demonstration of applicability of chiral mNBFs for electrochemical enantiorecognition, opens up new approaches into enantio(bio)sensing.
Versión del editorhttp://dx.doi.org/10.1016/j.bios.2018.01.024
URIhttp://hdl.handle.net/10261/165492
ISSN0956-5663
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